PMID- 32877823
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 191
DP  - 2020 Nov 30
TI  - Enantioseparation and determination of alminoprofen in rat plasma and its 
      application to a stereoselective pharmacokinetic study.
PG  - 113552
LID - S0731-7085(20)31438-2 [pii]
LID - 10.1016/j.jpba.2020.113552 [doi]
AB  - An enantioselective study of alminoprofen (AMF) in rat plasma was performed by a 
      rapid, specific and sensitive chiral liquid chromatography-tandem mass 
      spectrometry (LCMS/MS) method. A homemade beta-cyclodextrin (beta-CD) derivatized based 
      chiral column and a commercial polysaccharide type chiral column were selected 
      and evaluated. The former one per-4-chlorophenylcarbamate-beta-CD bonded chiral 
      stationary phase (CSP) which was synthesized in our lab produced the enhanced 
      enantioselective separation. The dextro-ketoprofen (d-KTF) was selected as the 
      internal standard (IS). The approach was linear in the concentration ranges of 
      1.00-20000.0 ng mL(-1) (r(2)>/=0.99) for each enantiomer. The mean recoveries of 
      R-(-)- and S-(+)-AMF at three spiked levels of 2.00, 1000.0 and 16000.0 ng mL(-1) 
      ranged from 92.0 %-96.1 %, and the intra-day and inter-day relative standard 
      deviations (RSDs) were within 8.9 %. The lower limit of quantification (LLOQ) 
      values of R-(-)- and S-(+)-AMF in rat plasma matrices were both 1.00 ng mL(-1). 
      The established method was successfully applied to a stereoselective 
      pharmacokinetic study of AMF enantiomers in rat plasma following oral 
      administration. The pharmacokinetic results revealed that S-(+)-AMF displayed 
      prominently higher C(max) and AUC values than R-(-)-enantiomer.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Sun, Jiayi
AU  - Sun J
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 
      Province, PR China.
FAU - Zhu, Yuanyuan
AU  - Zhu Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 
      Province, PR China.
FAU - Lin, Bin
AU  - Lin B
AD  - School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning Province, PR China.
FAU - Yu, Jia
AU  - Yu J
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 
      Province, PR China. Electronic address: yujia_yc@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200822
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Propionates)
RN  - 0255AHR9GJ (alminoprofen)
SB  - IM
MH  - Animals
MH  - Chromatography, Liquid
MH  - *Propionates
MH  - Rats
MH  - Reproducibility of Results
MH  - Stereoisomerism
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Alminoprofen enantiomers
OT  - LC-MS/MS
OT  - Stereoselective pharmacokineties
OT  - beta-cyclodextrin (beta-CD) derivatized chiral stationary phase
COIS- Declaration of Competing Interest None.
EDAT- 2020/09/03 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/03 06:00
PHST- 2020/04/25 00:00 [received]
PHST- 2020/08/10 00:00 [revised]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/03 06:00 [entrez]
AID - S0731-7085(20)31438-2 [pii]
AID - 10.1016/j.jpba.2020.113552 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2020 Nov 30;191:113552. doi: 10.1016/j.jpba.2020.113552. 
      Epub 2020 Aug 22.