PMID- 32877886
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20210609
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 172
DP  - 2020 Oct
TI  - Effects of peripheral and different inspiratory muscle training methods in 
      coronary artery disease patients with metabolic syndrome: A randomized-controlled 
      trial.
PG  - 106119
LID - S0954-6111(20)30259-6 [pii]
LID - 10.1016/j.rmed.2020.106119 [doi]
AB  - Background OBJECTIVE: To investigate the effects of peripheral muscle training 
      (PMT) and different inspiratory muscle training (IMT) methods on respiratory 
      functions, exercise capacity, and biochemistry parameters in coronary artery 
      disease patients with metabolic syndrome. METHODS: This prospective, 
      single-blind, randomized-controlled study included 60 patients of stable coronary 
      artery disease with metabolic syndrome (New York Heart Association [NYHA] Class 
      I-II, left ventricular ejection fraction >40%). Patients were randomly divided 
      into three groups: neuromuscular electrical stimulation (NMES) plus PMT group 
      (NMES + PMT group, n = 20), IMT plus PMT group (IMT + PMT group, n = 20) and PMT 
      group (PMT group, n = 20). Treatment continued for six weeks for all groups. The 
      NMES was applied to rectus abdominis, IMT was applied with 30% of maximal 
      inspiratory pressures, and PMT was applied at home. Spirometry, maximal 
      inspiratory and expiratory pressure, dyspnea scores, exercise stress test, and 
      biochemistry parameters were measured before and after training. RESULTS: There 
      were significant improvements in spirometric tests, respiratory muscle strength, 
      dyspnea scores, exercise capacity, fasting blood glucose, and antistreptolysin O 
      after treatment in all groups (p < 0.05). Significant improvements in C-reactive 
      protein and erythrocyte sedimentation rate were observed in NMES + PMT and 
      IMT + PMT groups (p < 0.05). Among the groups, there was a significant difference 
      in maximal inspiratory pressure (p = 0.02) and erythrocyte sedimentation rate 
      (p = 0.037) in favor of NMES + PMT group (p < 0.05). CONCLUSION: Our study 
      results showed significant improvements in respiratory functions, exercise 
      capacity, and biochemistry markers in all groups. Different IMT methods can be 
      used in cardiopulmonary rehabilitation to improve exercise intolerance in 
      coronary artery disease patients with metabolic syndrome. CLINICAL TRIAL 
      REGISTRATION NUMBER: NCT03523026.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Muammer, Kiymet
AU  - Muammer K
AD  - Department of Cardiology, Cardiology Institute, Istanbul University-Cerrahpasa, 
      Istanbul, Turkey.
FAU - Mutluay, Fatma
AU  - Mutluay F
AD  - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, 
      Medipol University, Istanbul, Turkey. Electronic address: 
      fmutluay@medipol.edu.tr.
FAU - Demir, Rengin
AU  - Demir R
AD  - Department of Cardiology, Cardiology Institute, Istanbul University-Cerrahpasa, 
      Istanbul, Turkey.
FAU - Ozkan, Alev Arat
AU  - Ozkan AA
AD  - Department of Cardiology, Cardiology Institute, Istanbul University-Cerrahpasa, 
      Istanbul, Turkey.
LA  - eng
SI  - ClinicalTrials.gov/NCT03523026
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200822
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Blood Glucose)
RN  - 9006-92-2 (Antistreptolysin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antistreptolysin/metabolism
MH  - Blood Glucose/metabolism
MH  - Blood Sedimentation
MH  - Breathing Exercises/*methods
MH  - C-Reactive Protein/metabolism
MH  - Coronary Artery Disease/etiology/metabolism/*physiopathology/*rehabilitation
MH  - Electric Stimulation Therapy
MH  - *Exercise Tolerance
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/complications/metabolism/*physiopathology/*rehabilitation
MH  - Middle Aged
MH  - Muscle Strength
MH  - Prospective Studies
MH  - Respiratory Muscles/*physiology
MH  - Spirometry
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Inspiratory muscle training
OT  - Metabolic syndrome
OT  - Neuromuscular electrical stimulation
OT  - Peripheral muscle training
EDAT- 2020/09/03 06:00
MHDA- 2021/06/10 06:00
CRDT- 2020/09/03 06:00
PHST- 2020/06/02 00:00 [received]
PHST- 2020/08/08 00:00 [revised]
PHST- 2020/08/10 00:00 [accepted]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2020/09/03 06:00 [entrez]
AID - S0954-6111(20)30259-6 [pii]
AID - 10.1016/j.rmed.2020.106119 [doi]
PST - ppublish
SO  - Respir Med. 2020 Oct;172:106119. doi: 10.1016/j.rmed.2020.106119. Epub 2020 Aug 
      22.