PMID- 32878149
OWN - NLM
STAT- MEDLINE
DCOM- 20210316
LR  - 20210316
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 17
DP  - 2020 Aug 31
TI  - Coumarin and Moracin Derivatives from Mulberry Leaves (Morus alba L.) with 
      Soluble Epoxide Hydrolase Inhibitory Activity.
LID - 10.3390/molecules25173967 [doi]
LID - 3967
AB  - This study identified three coumarins (1-3), and six moracin derivatives (4-9). 
      The structures of these natural compounds were determined by the spectroscopic 
      methods, including 1D and 2D NMR methods, and comparison with previous reported 
      data. All of the isolated compounds were assessed for the effects on the soluble 
      epoxide hydrolase (sEH) inhibitory activity. Among them, compounds 1-7 exhibited 
      significant inhibitory effect with 100% inhibitory, with IC(50) values of 6.9, 
      0.2, 15.9, 1.1, 1.2, 9.9, and 7.7 microM, respectively. A kinetic study revealed that 
      compounds 1-4, and 6 were competitive types of inhibitors, compounds 5 and 7 were 
      mixed types of inhibitors. These results suggest that moracin and coumarin 
      derivatives from mulberry leaves are significant sEH inhibitors.
FAU - Li, Hong Xu
AU  - Li HX
AD  - Shenzhen Key Laboratory of Marine Bioresource and Eco-Environmental Science, 
      College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, 
      China.
AD  - College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 
      518060, China.
FAU - Heo, Myungsook
AU  - Heo M
AD  - College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
FAU - Go, Younghoon
AU  - Go Y
AUID- ORCID: 0000-0002-2873-399X
AD  - Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 
      Daegu 41062, Korea.
FAU - Kim, Young Soo
AU  - Kim YS
AD  - Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 
      Daegu 41062, Korea.
FAU - Kim, Young Ho
AU  - Kim YH
AUID- ORCID: 0000-0002-7441-9459
AD  - College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
FAU - Yang, Seo Young
AU  - Yang SY
AUID- ORCID: 0000-0002-5248-1374
AD  - College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
FAU - Li, Wei
AU  - Li W
AUID- ORCID: 0000-0001-7272-7290
AD  - Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 
      Daegu 41062, Korea.
LA  - eng
GR  - KSN2013230/Ministry of Education, Science and Technology/
PT  - Journal Article
DEP - 20200831
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Benzofurans)
RN  - 0 (Coumarins)
RN  - A4VZ22K1WT (coumarin)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Benzofurans/*chemistry/isolation & purification/*pharmacology
MH  - Chemical Fractionation
MH  - Coumarins/*chemistry/isolation & purification/*pharmacology
MH  - Epoxide Hydrolases/*antagonists & inhibitors/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Molecular Structure
MH  - Morus/*chemistry
MH  - Plant Leaves/*chemistry
PMC - PMC7504814
OTO - NOTNLM
OT  - Morus alba
OT  - coumarin
OT  - moracin
OT  - soluble epoxide hydrolase (sEH)
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/04 06:00
MHDA- 2021/03/17 06:00
PMCR- 2020/08/31
CRDT- 2020/09/04 06:00
PHST- 2020/07/20 00:00 [received]
PHST- 2020/08/28 00:00 [revised]
PHST- 2020/08/31 00:00 [accepted]
PHST- 2020/09/04 06:00 [entrez]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2021/03/17 06:00 [medline]
PHST- 2020/08/31 00:00 [pmc-release]
AID - molecules25173967 [pii]
AID - molecules-25-03967 [pii]
AID - 10.3390/molecules25173967 [doi]
PST - epublish
SO  - Molecules. 2020 Aug 31;25(17):3967. doi: 10.3390/molecules25173967.