PMID- 32879167
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 155
IP  - 5
DP  - 2020
TI  - [Strong demands for the new preclinical assessment system of the CNS adverse 
      effects].
PG  - 295-298
LID - 10.1254/fpj.20029 [doi]
AB  - Human induced pluripotent stem cell-derived neurons (hiPSC-neurons) have 
      potentials to improve the predictability of the adverse effects (AEs) in the 
      human central nervous system (CNS). We have succeeded in reproducing the human 
      neural networks stably on dish. This is important because most of the CNS AEs 
      were caused not by the neuronal death but by the abnormal neural network 
      activities. Our group have been attempting to establish the in vitro assay system 
      to detect abnormal neural network activities by microelectrode array system 
      (MEA). Furthermore, the algorithm that can determine the synchronized burst 
      firing (SBF) objectively was developed in the collaboration of our iPS 
      Non-clinical Experiments for Nervous System (iNCENS) project and Consortium for 
      Safety Assessment using Human iPS Cells (CSAHi). iNCENS and CSAHi are also 
      involved in the international Life Sciences Institute (ILSI): Health and 
      Environmental Sciences Institute (HESI) HESI NeuTox MEA sub team, and are 
      participating in the pilot study using 12 compounds. In the big flow to develop 
      physiological CNS safety assessment system, we have to show Japan initiative 
      based on our innovative iPS technology we have developed so far.
FAU - Takahashi, Kanako
AU  - Takahashi K
AD  - Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of 
      Health Sciences.
FAU - Sato, Kaoru
AU  - Sato K
AD  - Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of 
      Health Sciences.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
SB  - IM
MH  - Action Potentials
MH  - Cells, Cultured
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Japan
MH  - Pilot Projects
EDAT- 2020/09/04 06:00
MHDA- 2020/11/03 06:00
CRDT- 2020/09/04 06:00
PHST- 2020/09/04 06:00 [entrez]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
AID - 10.1254/fpj.20029 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 2020;155(5):295-298. doi: 10.1254/fpj.20029.