PMID- 32879764
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210610
IS  - 2164-2591 (Print)
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 9
IP  - 9
DP  - 2020 Aug
TI  - Spectral-Domain Optical Coherence Tomography Is More Sensitive for 
      Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and 
      Near-Infrared Autofluorescence.
PG  - 8
LID - 10.1167/tvst.9.9.8 [doi]
LID - 8
AB  - PURPOSE: To analyze the appearance of structural abnormalities due to 
      hydroxychloroquine (HCQ) toxicity by spectral-domain optical coherence tomography 
      (SD-OCT) and short-wavelength autofluorescence (SW-AF) and near-infrared fundus 
      autofluorescence (NIR-AF) imaging. METHODS: This retrospective cohort study 
      included 88 eyes from 44 patients who had a history of or were currently taking 
      HCQ. SD-OCT, SW-AF, and NIR-AF images were analyzed by two independent graders 
      for the detection of HCQ-associated abnormalities. RESULTS: Sixty eyes (30 
      patients, 68%) presented with no abnormalities for either imaging modality. 
      Twenty eyes (10 patients, 23%) presented with parafoveal abnormalities (ellipsoid 
      zone attenuation and/or interdigitation zone continuity loss) in SD-OCT scans but 
      with qualitatively normal SW-AF and NIR-AF images. Eight eyes (four patients, 9%) 
      presented with bull's-eye maculopathy in SW-AF and NIR-AF images, with 
      corresponding outer retinal structures disrupted parafoveally in SD-OCT scans 
      ("flying saucer" sign). No patients presented with normal SD-OCT scans and 
      concurrent abnormalities in SW-AF or NIR-AF images. CONCLUSIONS: SD-OCT was more 
      sensitive in detecting structural abnormalities than either SW-AF or NIR-AF 
      imaging, suggesting its superiority as a screening imaging modality for HCQ 
      toxicity. Maculopathy and abnormalities in the retinal pigment epithelium from 
      HCQ toxicity can be appreciated in both SW-AF and NIR-AF images. TRANSLATIONAL 
      RELEVANCE: Although debate exists regarding the best imaging modalities for 
      screening patients for potential HCQ toxicity, our study supports the use of 
      SD-OCT over both SW-AF and NIR-AF imaging as a screening modality.
CI  - Copyright 2020 The Authors.
FAU - Jauregui, Ruben
AU  - Jauregui R
AD  - Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia 
      University Medical Center, New York, NY, USA.
AD  - Jonas Children's Vision Care Laboratory, New York, NY, USA.
FAU - Parmann, Rait
AU  - Parmann R
AD  - Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia 
      University Medical Center, New York, NY, USA.
AD  - Jonas Children's Vision Care Laboratory, New York, NY, USA.
FAU - Nuzbrokh, Yan
AU  - Nuzbrokh Y
AD  - Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia 
      University Medical Center, New York, NY, USA.
AD  - Jonas Children's Vision Care Laboratory, New York, NY, USA.
FAU - Tsang, Stephen H
AU  - Tsang SH
AD  - Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia 
      University Medical Center, New York, NY, USA.
AD  - Jonas Children's Vision Care Laboratory, New York, NY, USA.
AD  - Department of Pathology and Cell Biology, Columbia University Medical Center, New 
      York, NY, USA.
FAU - Sparrow, Janet R
AU  - Sparrow JR
AD  - Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia 
      University Medical Center, New York, NY, USA.
AD  - Jonas Children's Vision Care Laboratory, New York, NY, USA.
AD  - Department of Pathology and Cell Biology, Columbia University Medical Center, New 
      York, NY, USA.
LA  - eng
GR  - P30 EY019007/EY/NEI NIH HHS/United States
GR  - R01 EY024091/EY/NEI NIH HHS/United States
GR  - R01 EY024698/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200805
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
RN  - 4QWG6N8QKH (Hydroxychloroquine)
MH  - Fluorescein Angiography
MH  - Fundus Oculi
MH  - Humans
MH  - *Hydroxychloroquine/adverse effects
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
PMC - PMC7442882
OTO - NOTNLM
OT  - hydroxychloroquine
OT  - near-infrared fundus autofluorescence
OT  - optical coherence tomography
OT  - short-wavelength fundus autofluorescence
COIS- Disclosure: R. Jauregui, None; R. Parmann, None; Y. Nuzbrokh, None; S.H. Tsang, 
      None; J.R. Sparrow, None
EDAT- 2020/09/04 06:00
MHDA- 2020/09/04 06:01
PMCR- 2020/08/05
CRDT- 2020/09/04 06:00
PHST- 2020/03/12 00:00 [received]
PHST- 2020/06/26 00:00 [accepted]
PHST- 2020/09/04 06:00 [entrez]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2020/09/04 06:01 [medline]
PHST- 2020/08/05 00:00 [pmc-release]
AID - TVST-20-2415 [pii]
AID - 10.1167/tvst.9.9.8 [doi]
PST - epublish
SO  - Transl Vis Sci Technol. 2020 Aug 5;9(9):8. doi: 10.1167/tvst.9.9.8. eCollection 
      2020 Aug.