PMID- 32880800
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210723
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 199
IP  - 7
DP  - 2021 Jul
TI  - Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, 
      Reverse Inflammation, and Metabolic Alteration.
PG  - 2627-2634
LID - 10.1007/s12011-020-02363-w [doi]
AB  - Metabolic alterations and inflammation are regarded as hallmarks of cancer. 
      Glycolytic flux and intermediate accumulation lead to the production of building 
      blocks and NADPH which is important in protecting the cell from oxidative damage. 
      Inflammation causes the release of mediators responsible for regulating molecular 
      mechanism affecting metabolic pathways. CaFB due to its cis-diol-rich feature may 
      have the potential to interact with molecules taking part in cancer development. 
      This study was aimed to investigate the effects of CaFB on metabolic alterations 
      and inflammation in 7,12-dimethylbenz(a)anthracene 
      (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin cancer. For this 
      purpose, 92 Balb-c mice were distributed into 6 groups as control, CaFB, DMBA/TPA 
      (D-T), treatment 1 (T1), 2 (T2), and 3(T3). Apart from control and CaFB in other 
      groups, tumors initiated with 97.5-nmol DMBA and 6.5-nmol TPA. Treatment groups 
      received 3 mg/kg/day CaFB with DMBA (T1), with TPA (T2), and after tumor 
      formation (T3). In the D-T group, glyceraldehyde-3-phosphate dehydrogenase 
      (GAPDH) activity, 6-phosphogluconate dehydrogenase (PGD), glutathione (GSH), 
      interleukin 6 (IL-6), (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) levels increased 
      (p < 0.001) while malondialdehyde (MDA) levels decreased (p < 0.001) compared 
      with that in control. CaFB application ameliorated DMBA-TPA effect according to 
      the distribution time. It is noteworthy to consider CaFB as a potential 
      preventive agent in skin cancer development.
FAU - Kisacam, Mehmet Ali
AU  - Kisacam MA
AUID- ORCID: 0000-0003-0521-9434
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Mustafa Kemal 
      University, 31060, Hatay, Turkey. mkisacam@firat.edu.tr.
FAU - Kocamuftuoglu, Gonca Ozan
AU  - Kocamuftuoglu GO
AUID- ORCID: 0000-0001-6874-3669
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Mehmet AkifErsoy 
      University, 15030, Burdur, Turkey.
FAU - Ozan, Ibrahim Enver
AU  - Ozan IE
AUID- ORCID: 0000-0002-7274-5138
AD  - Department of Histology and Embryology, Faculty of Medicine, Firat University, 
      23200, Elazig, Turkey.
FAU - Yaman, Mehmet
AU  - Yaman M
AUID- ORCID: 0000-0002-3008-2671
AD  - Department of Chemistry, Faculty of Science, Firat University, 23200, Elazig, 
      Turkey.
FAU - Ozan, SemaTemizer
AU  - Ozan S
AUID- ORCID: 0000-0002-2274-1999
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Firat University, 
      23200, Elazig, Turkey.
LA  - eng
GR  - 2016-31-07-15-003./National Boron Institution of Turkey/
PT  - Journal Article
DEP - 20200903
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Borates)
RN  - 0 (Carcinogens)
RN  - 0 (calcium fructoborate)
RN  - 30237-26-4 (Fructose)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
SB  - IM
MH  - *9,10-Dimethyl-1,2-benzanthracene/toxicity
MH  - Animals
MH  - Borates
MH  - Carcinogens/toxicity
MH  - Fructose/analogs & derivatives
MH  - Inflammation/drug therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Skin
MH  - *Skin Neoplasms/chemically induced/drug therapy/prevention & control
OTO - NOTNLM
OT  - 6-Phosphogluconate dehydrogenase
OT  - Calcium fructoborate
OT  - Glyceraldehyde-3-phosphate dehydrogenase
OT  - Inflammation
OT  - Oxidative stress
OT  - Skin cancer
EDAT- 2020/09/04 06:00
MHDA- 2021/06/23 06:00
CRDT- 2020/09/04 06:00
PHST- 2020/07/02 00:00 [received]
PHST- 2020/08/25 00:00 [accepted]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/09/04 06:00 [entrez]
AID - 10.1007/s12011-020-02363-w [pii]
AID - 10.1007/s12011-020-02363-w [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2021 Jul;199(7):2627-2634. doi: 10.1007/s12011-020-02363-w. 
      Epub 2020 Sep 3.