PMID- 32880870
OWN - NLM
STAT- MEDLINE
DCOM- 20210803
LR  - 20210803
IS  - 2038-3312 (Electronic)
IS  - 2038-131X (Linking)
VI  - 73
IP  - 1
DP  - 2021 Feb
TI  - Low-molecular weight vs. unfractionated heparin for prevention of venous 
      thromboembolism in general surgery: a meta-analysis.
PG  - 75-83
LID - 10.1007/s13304-020-00872-w [doi]
AB  - To assess the association between low-molecular weight heparin (LMWH) and 
      unfractionated heparin (UFH) in the prevention of venous thromboembolism (VTE) 
      among participants undergoing general surgery. LMWH and UFH are the standard of 
      practice in the prevention of VTE in surgery. However, in the context of general 
      surgery, studies comparing the effectiveness of these treatments are limited. A 
      systematic search was conducted to find studies which examined the comparative 
      effectiveness between LMWH and UFH in the prophylaxis of VTE in the context of 
      general surgery. The number of events of VTE in groups receiving LMWH or UFH was 
      the primary outcome of interest, and was used to calculate odds-ratios. Amongst 
      33,068 participants pooled from twelve studies, the rate of VTE was 1.3% in those 
      treated with LMWH, and 3.1% in those treated with UFH. Although there was a wide 
      difference in rates due to clinical heterogeneity, there was no statistically 
      significant difference between treatment effects [OR 0.77; 95% CI 0.58-1.03; p 
      value = 0.0783; I(2)= 62.3%; 12 studies]. In terms of the sensitivity analysis, 
      sources overly contributing to heterogeneity were removed. The random-effects 
      model continued to show insignificance between LMWH and UFH in the prevention of 
      VTE in participants undergoing general surgery [OR 0.86; 95% CI 0.69-1.08; p 
      value = 0.2005; I(2)= 0%; 9 studies]. Results show an equal effectiveness in the 
      prevention of VTE between participants undergoing general surgery in those 
      allocated to receive LMWH to those allocated to receive UFH.
FAU - Nair, Prachi
AU  - Nair P
AD  - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, 
      Piscataway, NJ, USA.
FAU - Trivedi, Radhika
AU  - Trivedi R
AD  - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, 
      Piscataway, NJ, USA.
FAU - Hu, Patrick
AU  - Hu P
AD  - Department of Surgery, Rutgers New Jersey Medical School, 185 South Orange 
      Avenue, Suite MSB G530, Newark, NJ, 07103, USA.
FAU - Zhang, Yingting
AU  - Zhang Y
AD  - Robert Wood Johnson Library of the Health Sciences, New Brunswick, NJ, USA.
FAU - Merchant, Aziz M
AU  - Merchant AM
AUID- ORCID: 0000-0003-1091-938X
AD  - Department of Surgery, Rutgers New Jersey Medical School, 185 South Orange 
      Avenue, Suite MSB G530, Newark, NJ, 07103, USA. Aziz.merchant@rutgers.edu.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200903
PL  - Italy
TA  - Updates Surg
JT  - Updates in surgery
JID - 101539818
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Female
MH  - Heparin/*administration & dosage/adverse effects
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/adverse effects
MH  - Humans
MH  - Male
MH  - Postoperative Complications/*etiology/*prevention & control
MH  - Surgical Procedures, Operative/*adverse effects
MH  - Thrombocytopenia/chemically induced/epidemiology
MH  - Treatment Outcome
MH  - Venous Thromboembolism/*etiology/*prevention & control
OTO - NOTNLM
OT  - General surgery
OT  - Hemorrhage/chemically induced
OT  - Heparin/adverse effects
OT  - Postoperative complications/epidemiology
OT  - Thromboembolism
EDAT- 2020/09/04 06:00
MHDA- 2021/08/04 06:00
CRDT- 2020/09/04 06:00
PHST- 2020/06/20 00:00 [received]
PHST- 2020/08/23 00:00 [accepted]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2021/08/04 06:00 [medline]
PHST- 2020/09/04 06:00 [entrez]
AID - 10.1007/s13304-020-00872-w [pii]
AID - 10.1007/s13304-020-00872-w [doi]
PST - ppublish
SO  - Updates Surg. 2021 Feb;73(1):75-83. doi: 10.1007/s13304-020-00872-w. Epub 2020 
      Sep 3.