PMID- 32882764
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20240329
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 61
IP  - 9
DP  - 2020 Sep
TI  - Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 
      Years.
PG  - 797-804
LID - 10.3349/ymj.2020.61.9.797 [doi]
AB  - PURPOSE: Climate and lifestyle changes increase an individual's susceptibility to 
      various allergens and also the incidence of allergic diseases. We aimed to 
      examine the changes in sensitization rate for aeroallergens over a 10-year period 
      in Korean children. MATERIALS AND METHODS: We retrospectively reviewed the 
      medical records of 4493 children who visited the allergy clinic at a tertiary 
      hospital in Korea for allergic rhinitis or asthma from January 2009 to December 
      2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm 
      the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed 
      and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. 
      RESULTS: D. farinae was the most common sensitizing aeroallergen (45.9%) during 
      the 10-year span. The sensitization rate for tree pollen mixture (p for trend 
      <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for 
      trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during 
      the 10-year study period. Furthermore, the sensitization rate for multiple 
      allergens (>/=2) in 2018 increased significantly compared to that in 2009 (p for 
      trend=0.013). Compared with children without sensitization to D. farinae, those 
      with sensitization to D. farinae showed higher sensitization rates to other 
      aeroallergens (p for interaction <0.001). CONCLUSION: Children's sensitization 
      rate to cat and dog dander and weed and tree pollen mixtures significantly 
      increased during the 10-year period in Korea. Children with sensitization to D. 
      farinae are likely to be sensitized to other aeroallergens as well.
CI  - (c) Copyright: Yonsei University College of Medicine 2020.
FAU - Kim, Yea Ji
AU  - Kim YJ
AUID- ORCID: 0000-0002-4944-0379
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Lee, Mi Yeon
AU  - Lee MY
AUID- ORCID: 0000-0003-2119-9226
AD  - Division of Biostatistics, Department of R&D Management, Kangbuk Samsung 
      Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Yang, A Ram
AU  - Yang AR
AUID- ORCID: 0000-0003-4731-3701
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Sol, In Suk
AU  - Sol IS
AUID- ORCID: 0000-0003-2470-9682
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Kwak, Ji Hee
AU  - Kwak JH
AUID- ORCID: 0000-0001-6376-0427
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Jung, Hye Lim
AU  - Jung HL
AUID- ORCID: 0000-0003-0601-510X
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Shim, Jae Won
AU  - Shim JW
AUID- ORCID: 0000-0003-0101-3076
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Kim, Deok Soo
AU  - Kim DS
AUID- ORCID: 0000-0001-7156-9091
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Shim, Jung Yeon
AU  - Shim JY
AUID- ORCID: 0000-0001-9367-2233
AD  - Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea. jy7.shim@samsung.com.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/adverse effects/*immunology
MH  - Animals
MH  - Asthma/diagnosis/epidemiology/*immunology
MH  - Cats
MH  - Child
MH  - Dermatophagoides farinae
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Pollen/immunology
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/diagnosis/*immunology
PMC - PMC7471077
OTO - NOTNLM
OT  - Allergy
OT  - aeroallergen
OT  - children
OT  - sensitization
OT  - specific IgE
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2020/09/04 06:00
MHDA- 2020/09/18 06:00
PMCR- 2020/09/01
CRDT- 2020/09/04 06:00
PHST- 2020/04/07 00:00 [received]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/07/27 00:00 [accepted]
PHST- 2020/09/04 06:00 [entrez]
PHST- 2020/09/04 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - 61.797 [pii]
AID - 10.3349/ymj.2020.61.9.797 [doi]
PST - ppublish
SO  - Yonsei Med J. 2020 Sep;61(9):797-804. doi: 10.3349/ymj.2020.61.9.797.