PMID- 32883127
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20221207
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Print)
IS  - 1388-0209 (Linking)
VI  - 58
IP  - 1
DP  - 2020 Dec
TI  - Chinese medicinal plants for the potential management of high-altitude pulmonary 
      oedema and pulmonary hypertension.
PG  - 815-827
LID - 10.1080/13880209.2020.1804407 [doi]
AB  - CONTEXT: Despite the abundance of knowledge regarding high-altitude pulmonary 
      edoema (HAPE) and high-altitude pulmonary hypertension (HAPH), their prevalence 
      continues to be on the rise. Thus, there is an urgent need for newer safe, 
      effective, and relatively economic drug candidates. China is particularly known 
      for the use of medicinal plants. OBJECTIVE: This review summarizes the medicinal 
      plants used for HAPE and HAPH in the past 30 years, as well as some potential 
      plants. METHODS: Publications on HAPE and HAPH from 1990 to 2020 were identified 
      using Web of Science, PubMed, SCOPUS, Springer Link, Google Scholar databases, 
      Chinese Clinical Trial Registry and CNKI with the following keywords: 'medicinal 
      plants,' 'hypoxia,' 'high altitude pulmonary edema,' 'high altitude pulmonary 
      hypertension,' 'pathophysiology,' 'mechanisms,' 'prevention,' 'treatment,' 
      'human,' 'clinical,' 'safety,' and 'pharmacokinetics.' RESULTS: We found 26 
      species (from 20 families) out of 5000 plants which are used for HAPE and HAPH 
      prevention or treatment. Rhodiola rosea Linn. (Crassulaceae) is the most widely 
      utilized. The most involved family is Lamiaceae, which contains 5 species. 
      DISCUSSION AND CONCLUSIONS: We mainly reviewed the medicinal plants and 
      mechanisms for the treatment of HAPE and HAPH, and we also assessed related 
      toxicology experiments, pharmacokinetics and bioavailability. Potential medicinal 
      plants were also identified. Further research is needed to determine the 
      pharmacological effects and active ingredients of these potential medicinal 
      plants.
FAU - Wang, Tingting
AU  - Wang T
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
FAU - Hou, Jun
AU  - Hou J
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
FAU - Xiao, Wenjing
AU  - Xiao W
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
FAU - Zhang, Yaolei
AU  - Zhang Y
AD  - Faculty of Medical, Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.
FAU - Zhou, Longfu
AU  - Zhou L
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
FAU - Yuan, Li
AU  - Yuan L
AD  - Faculty of Medical, Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.
FAU - Yin, Xiaoqiang
AU  - Yin X
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
FAU - Chen, Xin
AU  - Chen X
AD  - Department of Laboratory Medicine, The Third People's Hospital of 
      Chengdu/Affiliated Hospital of Southwest, Jiaotong University, Chengdu, Sichuan, 
      P. R. China.
FAU - Hu, Yonghe
AU  - Hu Y
AD  - Department of Central Laboratory, The General Hospital of Western Theater 
      Command, Chengdu, Sichuan, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Altitude
MH  - Animals
MH  - Asian People
MH  - Biological Availability
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - Plants, Medicinal
MH  - Pulmonary Edema/*drug therapy
MH  - Rats
PMC - PMC8641673
OTO - NOTNLM
OT  - Rhodiola rosea. Lamiaceae
OT  - Hypoxia
OT  - high altitude disease
OT  - mechanisms
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2020/09/05 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/09/03
CRDT- 2020/09/05 06:00
PHST- 2020/09/05 06:00 [entrez]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/09/03 00:00 [pmc-release]
AID - 1804407 [pii]
AID - 10.1080/13880209.2020.1804407 [doi]
PST - ppublish
SO  - Pharm Biol. 2020 Dec;58(1):815-827. doi: 10.1080/13880209.2020.1804407.