PMID- 32883546
OWN - NLM
STAT- MEDLINE
DCOM- 20210827
LR  - 20210827
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 81
IP  - 12
DP  - 2020 Dec
TI  - Interaction between functional polymorphisms in FCER1A and TLR2 and the severity 
      of atopic dermatitis.
PG  - 709-713
LID - S0198-8859(20)30378-5 [pii]
LID - 10.1016/j.humimm.2020.08.002 [doi]
AB  - Dendritic cell toll-like receptors (TLRs) and the high-affinity immunoglobulin E 
      (IgE) receptor (FcepsilonRI) may biologically interact with regard to atopic dermatitis 
      (AD) development and, especially, severity. Our aim here was to test if such 
      interaction can be detected on the genetic level. The combined effect of the TLR2 
      gene (TLR2) rs4696480 and the FcepsilonRI alpha-chain gene (FCER1A) rs2252226 and rs2251746 
      polymorphisms on the AD severity as measured by SCORAD was assessed. The FCER1A 
      rs2252226 and TLR2 rs4696480 polymorphisms interacted with regard to SCORAD. 
      Higher SCORAD was observed in patients being the TLR2 rs4696480 major homozygotes 
      and carrying at the same time the FCER1A rs2252226 minor allele, compared to 
      those characterized by (any other of) the remaining combined rs2252226 and 
      rs4696480 genotypes. The observation of the epistatic effect of TLR2 and FCER1A 
      genetic variants on SCORAD is in line with the involvement of the interaction 
      TLRs-FcepsilonRI in the pathophysiology of AD.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Potaczek, Daniel P
AU  - Potaczek DP
AD  - Institute of Laboratory Medicine and Pathobiochemistry, Universities of Giessen 
      and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps 
      University Marburg, Marburg, Germany; Krakow Center for Medical Research and 
      Technology, John Paul II Hospital, Krakow, Poland.
FAU - Przytulska-Szczerbik, Aleksandra
AU  - Przytulska-Szczerbik A
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, Krakow, 
      Poland.
FAU - Bazan-Socha, Stanislawa
AU  - Bazan-Socha S
AD  - Department of Internal Medicine, Jagiellonian University Medical College, Krakow, 
      Poland.
FAU - Nastalek, Magdalena
AU  - Nastalek M
AD  - Faculty of Rehabilitation, University of Physical Education in Krakow, Poland.
FAU - Wojas-Pelc, Anna
AU  - Wojas-Pelc A
AD  - Department of Dermatology, Jagiellonian University Medical College, Krakow, 
      Poland.
FAU - Okumura, Ko
AU  - Okumura K
AD  - Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Nishiyama, Chiharu
AU  - Nishiyama C
AD  - Laboratory of Molecular Biology and Immunology, Department of Biological Science 
      and Technology, Tokyo University of Science, Tokyo, Japan.
FAU - Jurczyszyn, Artur
AU  - Jurczyszyn A
AD  - Department of Hematology, Jagiellonian University Medical College, Krakow, 
      Poland.
FAU - Undas, Anetta
AU  - Undas A
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, Krakow, 
      Poland; Institute of Cardiology, Jagiellonian University Medical College, Krakow, 
      Poland.
FAU - Wypasek, Ewa
AU  - Wypasek E
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, Krakow, 
      Poland; Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow 
      University, Krakow, Poland. Electronic address: e.wypasek@szpitaljp2.krakow.pl.
LA  - eng
PT  - Journal Article
DEP - 20200901
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (FCER1A protein, human)
RN  - 0 (Receptors, IgE)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Dermatitis, Atopic/blood/epidemiology/*genetics/physiopathology
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Poland/epidemiology
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Receptors, IgE/*genetics
MH  - *Severity of Illness Index
MH  - Toll-Like Receptor 2/*genetics
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Disease severity
OT  - FCER1A
OT  - SCORAD
OT  - TLR2
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/09/05 06:00
MHDA- 2021/08/28 06:00
CRDT- 2020/09/05 06:00
PHST- 2020/04/14 00:00 [received]
PHST- 2020/08/12 00:00 [revised]
PHST- 2020/08/12 00:00 [accepted]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2021/08/28 06:00 [medline]
PHST- 2020/09/05 06:00 [entrez]
AID - S0198-8859(20)30378-5 [pii]
AID - 10.1016/j.humimm.2020.08.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2020 Dec;81(12):709-713. doi: 10.1016/j.humimm.2020.08.002. Epub 
      2020 Sep 1.