PMID- 32883688
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220531
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 8
IP  - 1
DP  - 2020 Sep
TI  - Effect of diabetes on exosomal miRNA profile in patients with obesity.
LID - 10.1136/bmjdrc-2020-001403 [doi]
LID - e001403
AB  - INTRODUCTION: Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and 
      cardiovascular disease. T2DM increases the risk of cardiovascular-related death. 
      We investigated changes in circulating exosomal microRNA (miRNA) profiles in 
      patients with DM with obesity compared with patients without DM with obesity. 
      RESEARCH DESIGN AND METHODS: This prospective study involved 29 patients with 
      obesity (patients without DM=16, patients with DM=13) and healthy volunteers 
      (HVs) (n=18). We measured circulating levels of exosomal miRNAs by 
      next-generation sequencing and compared miRNA levels across the three groups. 
      RESULTS: The expression levels of 25 miRNAs (upregulated=14, downregulated=11) 
      differed between patients with obesity with DM and patients with obesity without 
      DM. Compared with HV, patients with DM with obesity had 53 dysregulated miRNAs. 
      Additionally, moving stepwise from HV to patients with obesity without DM to 
      patients with obesity with DM, there was a consistent increase in expression 
      levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels 
      of miR-6751-3p. CONCLUSIONS: Our data show that the exosomal miRNAs is altered by 
      dysregulated glucose metabolism in patients with obesity. This circulating 
      exosomal miRNA signature in patients with obesity with or without DM is a 
      potential biomarker and therapeutic target in these patients.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Kim, Hyoshik
AU  - Kim H
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Bae, Yun-Ui
AU  - Bae YU
AD  - Department of Clinical Endocrinology and Metabolism, Keimyung University School 
      of Medicine, Daegu, Kyungsang buk do, The Republic of Korea.
FAU - Lee, Haekyung
AU  - Lee H
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Kim, Hyoungnae
AU  - Kim H
AUID- ORCID: 0000-0002-5359-0214
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
AD  - Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Jeon, Jin Seok
AU  - Jeon JS
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
AD  - Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Noh, Hyunjin
AU  - Noh H
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
AD  - Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Han, Dong Cheol
AU  - Han DC
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
AD  - Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Byun, Dong Won
AU  - Byun DW
AD  - Division of Endocrinology and Metabolism, Soonchunhyang University Seoul 
      Hospital, Yongsan-gu, Seoul, The Republic of Korea.
FAU - Kim, Sang Hyun
AU  - Kim SH
AD  - Department of Surgery, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
FAU - Park, Hyeong Kyu
AU  - Park HK
AD  - Division of Endocrinology and Metabolism, Soonchunhyang University Seoul 
      Hospital, Yongsan-gu, Seoul, The Republic of Korea.
FAU - Ryu, Seongho
AU  - Ryu S
AD  - Soonchunhyang Institute of Med-bio Science (SIMS), Soonchunhyang University, 
      Asan, Chungcheongnam-do, The Republic of Korea ksoonhyo@schmc.ac.kr 
      ryu@sch.ac.kr.
FAU - Kwon, Soon Hyo
AU  - Kwon SH
AUID- ORCID: 0000-0002-4114-4196
AD  - Division of Nephrology, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea ksoonhyo@schmc.ac.kr ryu@sch.ac.kr.
AD  - Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital, Yongsan-gu, 
      Seoul, The Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - Obesity/genetics
MH  - Prospective Studies
PMC - PMC7473624
OTO - NOTNLM
OT  - biomarkers
OT  - diabetes mellitus
OT  - genetic
OT  - obesity
OT  - transcription
OT  - type 2
COIS- Competing interests: None declared.
EDAT- 2020/09/05 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/09/03
CRDT- 2020/09/05 06:00
PHST- 2020/03/26 00:00 [received]
PHST- 2020/07/01 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/09/05 06:00 [entrez]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/03 00:00 [pmc-release]
AID - 8/1/e001403 [pii]
AID - bmjdrc-2020-001403 [pii]
AID - 10.1136/bmjdrc-2020-001403 [doi]
PST - ppublish
SO  - BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001403. doi: 
      10.1136/bmjdrc-2020-001403.