PMID- 32884364
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1179-142X (Print)
IS  - 1179-142X (Electronic)
IS  - 1179-142X (Linking)
VI  - 13
DP  - 2020
TI  - Tamoxifen Induced Pachychoroid Pigment Epitheliopathy with Reversible Changes 
      After Drug Discontinuation.
PG  - 285-289
LID - 10.2147/IMCRJ.S256064 [doi]
AB  - We report a case of breast cancer with clinically significant retinal toxicity 
      induced by 7 years' Tamoxifen consumption in which patient's visual acuity and 
      paraclinical findings remarkably improved after drug discontinuation. A 
      49-year-old woman with a history of breast cancer and Tamoxifen consumption was 
      referred to our clinic for evaluation and treatment of gradual and progressive 
      decrease visual acuity of both eyes (more prominent in right eye). Funduscopy 
      showed bilateral macular pigmentary changes, with diffused tiny yellow crystals 
      and reduced macular tessellation. On spectral-domain optical coherence tomography 
      (SD-OCT), there was retinal pigment epithelium (RPE) abnormality and ellipsoid 
      zone discontinuity accompanied by retinal thinning and choroidal thickness that 
      was more prominent in the right eye. One year after discontinuation of the drug, 
      visual acuity was significantly improved and SD-OCT revealed some surprising 
      recoveries in the photoreceptor layers especially in her right eye.
CI  - (c) 2020 Ghassemi et al.
FAU - Ghassemi, Fariba
AU  - Ghassemi F
AUID- ORCID: 0000-0001-9423-9650
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Ocular Oncology Service, Farabi Eye Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Masoomian, Babak
AU  - Masoomian B
AUID- ORCID: 0000-0002-2249-2072
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Ocular Oncology Service, Farabi Eye Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Khodabandeh, Alireza
AU  - Khodabandeh A
AUID- ORCID: 0000-0002-3957-7515
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Khalili Pour, Elias
AU  - Khalili Pour E
AUID- ORCID: 0000-0001-8123-4375
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Bazvand, Fatemeh
AU  - Bazvand F
AUID- ORCID: 0000-0001-9720-2028
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Riazi-Esfahani, Hamid
AU  - Riazi-Esfahani H
AUID- ORCID: 0000-0003-2277-398X
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Ocular Oncology Service, Farabi Eye Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Case Reports
DEP - 20200727
PL  - New Zealand
TA  - Int Med Case Rep J
JT  - International medical case reports journal
JID - 101566269
PMC - PMC7434374
OTO - NOTNLM
OT  - breast cancer
OT  - pachychoroid
OT  - retinal toxicity
OT  - tamoxifen retinopathy
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/09/05 06:00
MHDA- 2020/09/05 06:01
PMCR- 2020/07/27
CRDT- 2020/09/05 06:00
PHST- 2020/04/02 00:00 [received]
PHST- 2020/07/07 00:00 [accepted]
PHST- 2020/09/05 06:00 [entrez]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2020/09/05 06:01 [medline]
PHST- 2020/07/27 00:00 [pmc-release]
AID - 256064 [pii]
AID - 10.2147/IMCRJ.S256064 [doi]
PST - epublish
SO  - Int Med Case Rep J. 2020 Jul 27;13:285-289. doi: 10.2147/IMCRJ.S256064. 
      eCollection 2020.