PMID- 32885688
OWN - NLM
STAT- MEDLINE
DCOM- 20210714
LR  - 20240402
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 27
IP  - 1
DP  - 2020 Dec
TI  - A promising drug delivery candidate (CS-g-PMDA-CYS-fused gold nanoparticles) for 
      inhibition of multidrug-resistant uropathogenic Serratia marcescens.
PG  - 1271-1282
LID - 10.1080/10717544.2020.1809557 [doi]
AB  - Antibiotic resistance amongst microbial pathogens is a mounting serious issue in 
      researchers and physicians. Various alternatives to overcome the 
      multidrug-resistant bacterial infections are under search, and biofilm growth 
      inhibition is one of them. In this investigation, a polymeric drug delivery 
      system loaded with multi-serratial drugs to improve the delivery of drugs against 
      urinary tract infection causative Serratia marcescens. The chitosan grafted 
      pyromellitic dianhydride - cysteine (CS-g-PMDA-CYS) was conjugated with AuNPs by 
      using the -SH group of CYS and RF (rifampicin) and INH (isoniazid) were loaded in 
      AuNPs-fused CS-g-PMDA-CYS system. Several physicochemical techniques 
      characterized this fabricated AuNPs/RF/INH/CS-g-PMDA-CYS system. The successful 
      encapsulation of RF and INH in AuNPs-fused CS-g-PMDA-CYS polymer had confirmed, 
      and it observed the loading capacity for RF and INH was 9.02% and 13.12%, 
      respectively. The in vitro drug discharge pattern was perceived high in pH 5.5 
      compared with pH 7.4. The AuNPs/RF/INH/CS-g-PMDA-CYS escalates 74% of 
      Caenorhabditis elegans survival during Serratia marcescens infection by aiming 
      biofilm development and virulence in S. marcescens. Author postulate that the 
      fabricated system is a promising drug carrier and delivery system for inhibition 
      of multidrug-resistant bacterias like S. marcescens.
FAU - Shi, Ping
AU  - Shi P
AD  - Management Office of Drug Clinical Trial Research, Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong.
FAU - Amarnath Praphakar, Rajendran
AU  - Amarnath Praphakar R
AD  - Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products 
      Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
FAU - Deepa, Sadhasivan
AU  - Deepa S
AD  - Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products 
      Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
FAU - Suganya, Kannan
AU  - Suganya K
AD  - Department of Microbial Technology, School of Biological Sciences, Madurai 
      Kamaraj University, Madurai, India.
FAU - Gupta, Prashant
AU  - Gupta P
AD  - Department of Balroga, Govt. Ayurved College, Raipur, Chhattisgarh, India.
FAU - Ullah, Riaz
AU  - Ullah R
AD  - Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Bari, Ahmed
AU  - Bari A
AD  - Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Murugan, Marudhamuthu
AU  - Murugan M
AD  - Department of Microbial Technology, School of Biological Sciences, Madurai 
      Kamaraj University, Madurai, India.
FAU - Rajan, Mariappan
AU  - Rajan M
AUID- ORCID: 0000-0001-9569-8744
AD  - Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products 
      Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Benzoates)
RN  - 0 (Gold Compounds)
RN  - 11118-27-7 (gold chloride)
RN  - 2Z22T30QZQ (pyromellitic dianhydride)
RN  - 9012-76-4 (Chitosan)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*administration & dosage/chemistry
MH  - Benzoates/administration & dosage/chemical synthesis
MH  - Caenorhabditis elegans/drug effects/microbiology/physiology
MH  - Chitosan/administration & dosage/chemical synthesis
MH  - Cysteine/administration & dosage/chemical synthesis
MH  - Drug Delivery Systems/*methods
MH  - Drug Resistance, Multiple, Bacterial/*drug effects/physiology
MH  - Gold Compounds/*administration & dosage/chemical synthesis
MH  - Metal Nanoparticles/*administration & dosage/chemistry
MH  - Microbial Sensitivity Tests/methods
MH  - Serratia Infections/drug therapy
MH  - Serratia marcescens/*drug effects/physiology
MH  - Urinary Tract Infections/drug therapy
MH  - X-Ray Diffraction/methods
PMC - PMC8216475
OTO - NOTNLM
OT  - Serratia marcescens
OT  - Antibiotic resistance
OT  - gold nanoparticle
OT  - pH-sensitive drug delivery
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/09/05 06:00
MHDA- 2021/07/15 06:00
PMCR- 2020/09/04
CRDT- 2020/09/05 06:00
PHST- 2020/09/05 06:00 [entrez]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2021/07/15 06:00 [medline]
PHST- 2020/09/04 00:00 [pmc-release]
AID - 1809557 [pii]
AID - 10.1080/10717544.2020.1809557 [doi]
PST - ppublish
SO  - Drug Deliv. 2020 Dec;27(1):1271-1282. doi: 10.1080/10717544.2020.1809557.