PMID- 32886744
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 145
IP  - 4
DP  - 2021 Apr 1
TI  - Paraganglia of the Gallbladder: An Underrecognized Incidental Finding and 
      Potential Diagnostic Pitfall.
PG  - 437-440
LID - 10.5858/arpa.2020-0041-OA [doi]
AB  - CONTEXT.-: The identification of paraganglia (PG) in the gallbladder (GB) is 
      infrequent, and easily overlooked as it is not something routinely reported. 
      Occasionally they may be misinterpreted as neoplastic cells, such as low-grade 
      carcinomas, germ cell tumors, or because of their close resemblance to 
      neuroendocrine cells, as low-grade neuroendocrine neoplasms. OBJECTIVE.-: To 
      evaluate the incidence and histological features of PG of the GB in patients that 
      underwent cholecystectomy, and discuss the potential misinterpretation of these 
      benign structures as clusters of neoplastic cells. DESIGN.-: A retrospective 
      study of cholecystectomy specimens performed during a 6-month period were 
      reviewed for identification of PG. Immunohistochemical studies for chromogranin, 
      synaptophysin, S100, and cytokeratin AE1/AE3 were performed in selected cases. 
      RESULTS.-: A total of 365 GBs were reviewed and in 16 cases (4.4%) PG was 
      identified within the subserosal connective tissue of the GB wall or cystic duct 
      adjacent to small capillaries, nerves, and ganglia. They consisted of 
      well-demarcated, lobular structures ranging in size from 0.2 to 0.5 cm, which 
      were predominantly composed of chief cells, with strong expression for 
      chromogranin and synaptophysin and negative CKAE1/AE3, and a minor component of 
      S100-positive sustentacular cells. CONCLUSIONS.-: PG is an uncommon finding with 
      a prevalence of 4.4% in our study. Awareness of their location, histologic 
      features, and immunohistochemical profile may help practicing pathologists to 
      confirm their benign nature, avoid a misdiagnosis of malignancy, and prevent 
      unnecessary diagnostic work-up and treatment.
CI  - (c) 2021 College of American Pathologists.
FAU - Ramlal, Bharat
AU  - Ramlal B
AD  - From the Department of Pathology & Laboratory Medicine, Hartford Hospital, 
      Hartford, Connecticut.
FAU - Voytek, Theresa
AU  - Voytek T
AD  - From the Department of Pathology & Laboratory Medicine, Hartford Hospital, 
      Hartford, Connecticut.
FAU - Ligato, Saverio
AU  - Ligato S
AD  - From the Department of Pathology & Laboratory Medicine, Hartford Hospital, 
      Hartford, Connecticut.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Cholecystectomy
MH  - Diagnosis, Differential
MH  - Female
MH  - Gallbladder/chemistry/*pathology/surgery
MH  - Gallbladder Neoplasms/chemistry/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - *Incidental Findings
MH  - Male
MH  - Middle Aged
MH  - Paraganglia, Chromaffin/chemistry/*pathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
EDAT- 2020/09/05 06:00
MHDA- 2021/06/01 06:00
CRDT- 2020/09/04 17:10
PHST- 2020/05/15 00:00 [accepted]
PHST- 2020/09/05 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
PHST- 2020/09/04 17:10 [entrez]
AID - 441480 [pii]
AID - 10.5858/arpa.2020-0041-OA [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2021 Apr 1;145(4):437-440. doi: 10.5858/arpa.2020-0041-OA.