PMID- 32887288
OWN - NLM
STAT- MEDLINE
DCOM- 20210310
LR  - 20210310
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 17
DP  - 2020 Sep 2
TI  - Wheat Bran Extract Regulates Mast Cell-Mediated Allergic Responses In Vitro and 
      In Vivo.
LID - 10.3390/molecules25173997 [doi]
LID - 3997
AB  - In the present study the effects and molecular mechanisms of wheat bran (WB), the 
      hard outer layer of the wheat kernel used in food ingredients, on mast 
      cell-mediated allergic responses in vitro and in vivo were investigated. The 
      water extract of WB inhibited degranulation and expression of allergic and 
      inflammatory mediators such as tumor necrosis factor-alpha, cyclooxygenase-2 and 
      inducible nitric oxide synthase in antigen-stimulated RBL-2H3 cells. These 
      anti-allergic activities of WB were mediated by the inactivation of extracellular 
      signal-regulated kinase and p38 mitogen-activated protein kinase, which play 
      important roles in degranulation and expression of various allergic and 
      inflammatory molecules. In agreement with its in vitro effects, WB inhibited 
      immunoglobulin E (IgE)/antigen-induced and compound 48/80-induced anaphylactic 
      reactions in vivo. Taken together, these findings suggest the pharmacological 
      potential of WB in the regulation of allergic diseases, including allergic 
      rhinitis, atopic dermatitis, asthma and anaphylaxis.
FAU - Lee, Jae Yeon
AU  - Lee JY
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
FAU - Ahn, Eun-Kyung
AU  - Ahn EK
AD  - Bio-Center, Gyeonggido Business and Science Accelerator, Gwanggyo-ro 147, 
      Yeoungtong, Suwon, Gyeonggi 16229, Korea.
FAU - Park, Ju-Hyoung
AU  - Park JH
AD  - College of Pharmacy, Dankook University, Dandae-ro 119, Dongnam, Cheonan, 
      Chungnam 31116, Korea.
FAU - Oh, Joa Sub
AU  - Oh JS
AD  - College of Pharmacy, Dankook University, Dandae-ro 119, Dongnam, Cheonan, 
      Chungnam 31116, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200902
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antigens)
RN  - 0 (Dietary Fiber)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Cell Degranulation/drug effects
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Dietary Fiber/*pharmacology
MH  - Hypersensitivity/*pathology
MH  - Immunoglobulin E/metabolism
MH  - Inflammation Mediators/metabolism
MH  - MAP Kinase Signaling System/drug effects
MH  - Mast Cells/drug effects/*pathology/physiology
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - beta-N-Acetylhexosaminidases/metabolism
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
PMC - PMC7504747
OTO - NOTNLM
OT  - allergy
OT  - anaphylaxis
OT  - mitogen-activated protein kinase
OT  - wheat bran
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/06 06:00
MHDA- 2021/03/11 06:00
PMCR- 2020/09/02
CRDT- 2020/09/05 01:03
PHST- 2020/08/15 00:00 [received]
PHST- 2020/08/29 00:00 [revised]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/09/05 01:03 [entrez]
PHST- 2020/09/06 06:00 [pubmed]
PHST- 2021/03/11 06:00 [medline]
PHST- 2020/09/02 00:00 [pmc-release]
AID - molecules25173997 [pii]
AID - molecules-25-03997 [pii]
AID - 10.3390/molecules25173997 [doi]
PST - epublish
SO  - Molecules. 2020 Sep 2;25(17):3997. doi: 10.3390/molecules25173997.