PMID- 32888295
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 59
IP  - 1
DP  - 2021 Jan 4
TI  - Long-term experience with the one-and-a-half ventricle repair for simple and 
      complex congenital heart defects.
PG  - 244-252
LID - 10.1093/ejcts/ezaa289 [doi]
AB  - OBJECTIVES: The one-and-a-half ventricle repair (1.5VR) is a surgical alternative 
      to Fontan circulation or high-risk biventricular repair in patients with complex 
      congenital heart disease (CHD) with a hypoplastic right ventricle (RV). We report 
      our 25 years of experience to evaluate whether the degree of anatomical 
      complexity of the CHD can affect long-term outcomes. METHODS: This is a 
      retrospective study including patients undergoing 1.5VR between 1994 and 2018. 
      Clinical records and operative reports were reviewed. Follow-up data were 
      collected from all survivors at the last evaluation or by phone contact. RESULTS: 
      Twenty-nine patients underwent 1.5VR [median age: 3.5 years, interquartile range 
      (IQR) 0.8-7.8]. Fifteen patients had 'simple' (i.e. confined to right heart 
      lesions) anatomical characteristics (48.3%); the median tricuspid valve annulus 
      z-score was -3.5 (IQR -6.2 to +3.6). There were no operative deaths. The median 
      hospital stay was 21 days (IQR 10-33), with postoperative complications in 21 
      patients (75.8%). At a median follow-up of 13.2 years (IQR 3.2-25.6 years; 
      completeness 96.6%), there were 3 late deaths. There was no significant 
      difference in survival and in freedom from adverse events between simple and 
      complex anatomy groups. However, stress test findings showed a tendency towards a 
      higher maximum oxygen uptake in the simple group (P = 0.055). CONCLUSIONS: The 
      1.5VR strategy is an effective low-risk surgical option for patients with CHD 
      with hypoplastic RV. When it is planned from birth, late outcomes can be 
      satisfactory. In our experience, the presence of associated major cardiac 
      anomalies was not associated with either worse early or long-term outcomes and 
      functional status.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      European Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Cabrelle, Giulio
AU  - Cabrelle G
AD  - Pediatric Cardiology, Department of Woman's and Child's Health, University of 
      Padua, Padova, Italy.
FAU - Castaldi, Biagio
AU  - Castaldi B
AD  - Pediatric Cardiology, Department of Woman's and Child's Health, University of 
      Padua, Padova, Italy.
FAU - Vedovelli, Luca
AU  - Vedovelli L
AD  - Unit of Biostatistics, Epidemiology and Public Health, Department of 
      Cardio-thoracic-vascular Sciences and Public Health, University of Padova, 
      Padova, Italy.
FAU - Gregori, Dario
AU  - Gregori D
AD  - Unit of Biostatistics, Epidemiology and Public Health, Department of 
      Cardio-thoracic-vascular Sciences and Public Health, University of Padova, 
      Padova, Italy.
FAU - Vida, Vladimiro L
AU  - Vida VL
AD  - Pediatric and Congenital Cardiac Surgery, Department of Cardio-thoracic-vascular 
      Sciences and Public Health, University of Padova, Padova, Italy.
FAU - Padalino, Massimo A
AU  - Padalino MA
AD  - Pediatric and Congenital Cardiac Surgery, Department of Cardio-thoracic-vascular 
      Sciences and Public Health, University of Padova, Padova, Italy.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Child, Preschool
MH  - Follow-Up Studies
MH  - *Heart Defects, Congenital/surgery
MH  - *Heart Ventricles/diagnostic imaging/surgery
MH  - Humans
MH  - Oxygen
MH  - Oxygen Consumption
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Complex anatomy
OT  - Congenital heart disease
OT  - Long-term outcomes
OT  - One-and-a-half ventricle repair
EDAT- 2020/09/06 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/05 08:33
PHST- 2020/04/02 00:00 [received]
PHST- 2020/06/17 00:00 [revised]
PHST- 2020/06/27 00:00 [accepted]
PHST- 2020/09/06 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/05 08:33 [entrez]
AID - 5901844 [pii]
AID - 10.1093/ejcts/ezaa289 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2021 Jan 4;59(1):244-252. doi: 10.1093/ejcts/ezaa289.