PMID- 32888477
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20210902
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Linking)
VI  - 30
IP  - 21
DP  - 2020 Nov 2
TI  - A Natural Mutational Event Uncovers a Life History Trade-Off via Hormonal 
      Pleiotropy.
PG  - 4142-4154.e9
LID - S0960-9822(20)31158-1 [pii]
LID - 10.1016/j.cub.2020.08.004 [doi]
AB  - Environmental signals often control central life history decisions, including the 
      choice between reproduction and somatic maintenance. Such adaptive developmental 
      plasticity occurs in the nematode Caenorhabditis elegans, where environmental 
      cues govern whether larvae will develop directly into reproducing adults or 
      arrest their development to become stress-resistant dauer larvae. Here, we 
      identified a natural variant underlying enhanced sensitivity to dauer-inducing 
      cues in C. elegans: a 92-bp deletion in the cis-regulatory region of the gene 
      eak-3. This deletion reduces synthesis or activity of the steroid hormone 
      dafachronic acid (DA), thereby increasing environmental sensitivity for dauer 
      induction. Consistent with known pleiotropic roles of DA, this eak-3 variant 
      significantly slows down reproductive growth. We experimentally show that, 
      although the eak-3 deletion can provide a fitness advantage through facilitated 
      dauer production in stressful environments, this allele becomes rapidly 
      outcompeted in favorable environments. The identified eak-3 variant therefore 
      reveals a trade-off in how hormonal responses influence both the pace of 
      developmental timing and the way in which environmental sensitivity controls 
      adaptive plasticity. Together, our results show how a single mutational event 
      altering hormonal signaling can lead to the emergence of a complex life history 
      trade-off.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Billard, Benedicte
AU  - Billard B
AD  - Universite Cote d'Azur, CNRS, Inserm, IBV, Nice, France.
FAU - Vigne, Paul
AU  - Vigne P
AD  - Universite Cote d'Azur, CNRS, Inserm, IBV, Nice, France.
FAU - Braendle, Christian
AU  - Braendle C
AD  - Universite Cote d'Azur, CNRS, Inserm, IBV, Nice, France. Electronic address: 
      braendle@unice.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200903
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Cholestenes)
RN  - 0 (dafachronic acid)
SB  - IM
CIN - Curr Biol. 2020 Nov 2;30(21):R1314-R1316. PMID: 33142100
MH  - Adaptation, Physiological/genetics
MH  - Alleles
MH  - Animals
MH  - Caenorhabditis elegans/*physiology
MH  - Caenorhabditis elegans Proteins/*genetics/metabolism
MH  - Cholestenes/*metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Genetic Pleiotropy
MH  - Larva/genetics/*growth & development
MH  - Mutation
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Sequence Deletion
MH  - Signal Transduction
OTO - NOTNLM
OT  - C. elegans
OT  - adaptive developmental plasticity
OT  - dauer induction
OT  - eak-3
OT  - environmental sensitivity
OT  - genotype-by-environment interactions
OT  - hormonal pleiotropy
OT  - life history trade-off
OT  - natural variation
OT  - steroid hormones
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2020/09/06 06:00
MHDA- 2021/09/03 06:00
CRDT- 2020/09/05 12:14
PHST- 2020/06/17 00:00 [received]
PHST- 2020/07/31 00:00 [revised]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/09/06 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2020/09/05 12:14 [entrez]
AID - S0960-9822(20)31158-1 [pii]
AID - 10.1016/j.cub.2020.08.004 [doi]
PST - ppublish
SO  - Curr Biol. 2020 Nov 2;30(21):4142-4154.e9. doi: 10.1016/j.cub.2020.08.004. Epub 
      2020 Sep 3.