PMID- 32888767
OWN - NLM
STAT- MEDLINE
DCOM- 20201027
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 81
IP  - 10-11
DP  - 2020 Oct-Nov
TI  - Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An 
      in silico glance.
PG  - 588-595
LID - S0198-8859(20)30377-3 [pii]
LID - 10.1016/j.humimm.2020.08.001 [doi]
AB  - Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no 
      clinically approved treatment yet. Bioinformatics represent an outstanding 
      approach to reveal key immunogenic regions in viral proteins. Here, five severe 
      acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins 
      (NSPs) (NSP7, NSP8, NSP9, NSP12, and NSP13) were screened to identify potential 
      human leukocyte antigen (HLA) binding peptides. These peptides showed robust 
      viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. 
      Interestingly, several peptides showed affinity by HLA class I (HLA-I) alleles 
      that commonly activates to natural killer (NK) cells. Notably, HLA biding 
      peptides are conserved among SARS-CoV-2, severe acute respiratory syndrome 
      coronavirus (SARS-CoV), and Middle Eastern respiratory syndrome coronavirus 
      (MERS-CoV). Interestingly, HLA-I and HLA class II (HLA-II) binding peptides 
      induced humoral and cell-mediated responses after in silico vaccination. These 
      results may open further in vitro and in vivo investigations to develop novel 
      therapeutic strategies against coronaviral infections.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Marchan, Jose
AU  - Marchan J
AD  - Centro de Medicina Experimental, Instituto Venezolano de Investigaciones 
      Cientificas, Venezuela. Electronic address: josemarch@ivic.gob.ve.
LA  - eng
PT  - Journal Article
DEP - 20200813
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (HLA Antigens)
RN  - 0 (Vaccines, Subunit)
RN  - 0 (Viral Nonstructural Proteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Amino Acid Sequence
MH  - Betacoronavirus/genetics/*immunology
MH  - COVID-19
MH  - COVID-19 Vaccines
MH  - Conserved Sequence/*immunology
MH  - Coronavirus Infections/blood/*immunology/prevention & control/therapy/virology
MH  - HLA Antigens/*immunology/metabolism
MH  - Humans
MH  - Immunity, Cellular/immunology
MH  - Immunity, Humoral/immunology
MH  - Killer Cells, Natural/immunology/metabolism
MH  - Middle East Respiratory Syndrome Coronavirus/genetics/immunology
MH  - Molecular Docking Simulation
MH  - Pandemics
MH  - Pneumonia, Viral/blood/*immunology/therapy/virology
MH  - Severe acute respiratory syndrome-related coronavirus/genetics/immunology
MH  - SARS-CoV-2
MH  - Vaccines, Subunit/immunology
MH  - Viral Nonstructural Proteins/genetics/*immunology/metabolism
MH  - Viral Vaccines/immunology
PMC - PMC7425717
OTO - NOTNLM
OT  - COVID-19
OT  - Epitopes
OT  - In silico
OT  - MERS
OT  - Non-structural proteins
OT  - SARS
EDAT- 2020/09/06 06:00
MHDA- 2020/10/28 06:00
PMCR- 2020/08/13
CRDT- 2020/09/05 12:18
PHST- 2020/07/02 00:00 [received]
PHST- 2020/08/08 00:00 [revised]
PHST- 2020/08/10 00:00 [accepted]
PHST- 2020/09/06 06:00 [pubmed]
PHST- 2020/10/28 06:00 [medline]
PHST- 2020/09/05 12:18 [entrez]
PHST- 2020/08/13 00:00 [pmc-release]
AID - S0198-8859(20)30377-3 [pii]
AID - 10.1016/j.humimm.2020.08.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2020 Oct-Nov;81(10-11):588-595. doi: 10.1016/j.humimm.2020.08.001. 
      Epub 2020 Aug 13.