PMID- 32888789 OWN - NLM STAT- MEDLINE DCOM- 20211124 LR - 20221207 IS - 1873-460X (Electronic) IS - 1056-8727 (Linking) VI - 34 IP - 11 DP - 2020 Nov TI - Sex-influenced association between free triiodothyronine levels and poor glycemic control in euthyroid patients with type 2 diabetes mellitus. PG - 107701 LID - S1056-8727(20)30469-4 [pii] LID - 10.1016/j.jdiacomp.2020.107701 [doi] AB - OBJECTIVE: The study investigated the association between free triiodothyronine (FT3) and poor glycemic control with different definitions in euthyroid patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study which included 2172 patients from National Metabolic Management Center in Ruijin Hospital. The association between thyroid function and glycated hemoglobin A1c (HbA1c) was determined by multiple liner regression models. The association between FT3 and poor glycemic control was further determined by binary logistic regression models. Two definitions of poor glycemic control (HbA1c >/= 7% and HbA1c >/= 8%) were applied when we analyzed the association. RESULTS: Prevalence of HbA1c >/= 7% and HbA1c >/= 8% were 63.8% and 39.3%, respectively. After adjusting for confounding factors, FT3, rather than free tetraiodothyronine (FT4) or thyroid stimulating hormone (TSH), was independently associated with HbA1c (beta = -0.104, P = 0.002). Further analysis after gender stratification showed that the association was only found in males (beta = -0.164, P < 0.001). We further analyzed the association between FT3 quartiles and poor glycemic control. FT3 quartiles were not significantly associated with the risk of HbA1c >/= 7% before and after adjusting for confounding factors in both genders. FT3 quartiles were negatively associated with the risk of HbA1c >/= 8% only in males, independent of traditional risk factors for poor glycemic control (P for trend = 0.030). CONCLUSIONS: FT3 in the reference range was significantly associated with reduced risk of HbA1c >/= 8% in males, independent of traditional risk factors for poor glycemic control. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Zhang, Tianyue AU - Zhang T AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Shi, Juan AU - Shi J AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Peng, Ying AU - Peng Y AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Shujie AU - Wang S AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Mu, Qian AU - Mu Q AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Fang, Qianhua AU - Fang Q AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Gu, Weiqiong AU - Gu W AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Hong, Jie AU - Hong J AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Yifei AU - Zhang Y AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: feifei-a@163.com. FAU - Wang, Weiqing AU - Wang W AD - Shanghai National Clinical Research Center for Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wqingw61@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200731 PL - United States TA - J Diabetes Complications JT - Journal of diabetes and its complications JID - 9204583 RN - 0 (Glycated Hemoglobin A) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/blood/epidemiology MH - Female MH - Glycated Hemoglobin MH - *Glycemic Control MH - Humans MH - Male MH - Sex Factors MH - *Triiodothyronine/blood OTO - NOTNLM OT - Free triiodothyronine OT - Glycemic control OT - Type 2 diabetes mellitus COIS- Declaration of competing interest The authors declare that they have no competing interests. Disclosures The authors declare that they have no competing interests. EDAT- 2020/09/06 06:00 MHDA- 2021/11/25 06:00 CRDT- 2020/09/05 12:19 PHST- 2020/04/13 00:00 [received] PHST- 2020/07/07 00:00 [revised] PHST- 2020/07/26 00:00 [accepted] PHST- 2020/09/06 06:00 [pubmed] PHST- 2021/11/25 06:00 [medline] PHST- 2020/09/05 12:19 [entrez] AID - S1056-8727(20)30469-4 [pii] AID - 10.1016/j.jdiacomp.2020.107701 [doi] PST - ppublish SO - J Diabetes Complications. 2020 Nov;34(11):107701. doi: 10.1016/j.jdiacomp.2020.107701. Epub 2020 Jul 31.