PMID- 32890232
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 22
IP  - 3
DP  - 2021 Mar 1
TI  - Ventricular arrhythmias in Takotsubo Syndrome: incidence, predictors and clinical 
      outcomes.
PG  - 180-189
LID - 10.2459/JCM.0000000000001106 [doi]
AB  - AIMS: To investigate predictors of the occurrence of subacute ventricular 
      arrhythmias (VAs), defined as any VAs presenting after 48 h from admission in 
      patients with Takotsubo Syndrome (TTS), and to evaluate the related in-hospital 
      mortality. METHODS: This is a retrospective single-center study enrolling 
      patients admitted between 2012 and 2017 with TTS according to International 
      Takotsubo diagnostic criteria. Data collection included ECG on admission and at 
      48 h, telemetry monitoring and transthoracic echocardiogram. RESULTS: We enrolled 
      93 patients; during in-hospital stay (mean 14 +/- 16 days) subacute VAs occurred in 
      25% of patients (VAs group). Life-threatening VAs occurred in 6% of patients (3 
      sustained ventricular tachycardia, 1 torsade de pointes, 1 ventricular 
      fibrillation) and not life-threatening VAs in 19% (6 non-sustained ventricular 
      tachycardia and 12 premature ventricular contractions > 2000 in 24 h). Mortality 
      was higher in the VAs than in the non-VAs group (P = 0.03), without differences 
      in terms of life-threatening and not life-threatening subacute VAs (P = 0.65) and 
      VAs on admission (P = 0.25). Logistic regression identified the following 
      independent predictors of subacute VAs occurrence: VAs on admission odds ratio 
      [OR] 22.5 (3.9-131.8), P = 0.001], New York Heart Association (NYHA) class 
      III-IV on admission [OR 6.7 (1.3- 34.0), P = 0.021] and QTc at 48 h [OR 1.01 
      (1.00-1.03), P = 0.046]. CONCLUSION: TTS patients with VAs and NYHA class III-IV 
      on admission and higher QTc at 48 h are at increased risk of subacute VAs 
      occurrence, associated with higher in-hospital mortality. Awareness of this 
      potential complication is critical for proper patients management.
CI  - Copyright (c) 2020 Italian Federation of Cardiology - I.F.C. All rights reserved.
FAU - Pelargonio, Gemma
AU  - Pelargonio G
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
AD  - Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - La Rosa, Giulio
AU  - La Rosa G
AD  - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial 
      Pathophysiology Area. Madrid, Spain.
FAU - Di Stasio, Enrico
AU  - Di Stasio E
AD  - Dipartimento di Scienze di Laboratorio ed Infettivologiche, Fondazione 
      Policlinico Universitario Agostino Gemelli IRCCS.
AD  - Istituto di Biochimica e Biochimica Clinica, Universita Cattolica del Sacro 
      Cuore, Largo F. Vito 1, Rome, Italy.
FAU - Narducci, Maria Lucia
AU  - Narducci ML
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Rocco, Erica
AU  - Rocco E
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Angelini, Alessio
AU  - Angelini A
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Pinnacchio, Gaetano
AU  - Pinnacchio G
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Bencardino, Gianluigi
AU  - Bencardino G
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Perna, Francesco
AU  - Perna F
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Comerci, Gianluca
AU  - Comerci G
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Catania, Fiammetta
AU  - Catania F
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
FAU - Crea, Filippo
AU  - Crea F
AD  - Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico 
      Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Rome, Italy.
AD  - Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Aged
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Hospital Mortality/trends
MH  - Humans
MH  - Incidence
MH  - Italy/epidemiology
MH  - Male
MH  - Radionuclide Ventriculography/methods
MH  - Retrospective Studies
MH  - Tachycardia, Ventricular/diagnosis/epidemiology/*etiology
MH  - Takotsubo Cardiomyopathy/*complications/physiopathology
MH  - Telemetry
EDAT- 2020/09/06 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/09/05 17:07
PHST- 2020/09/06 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/09/05 17:07 [entrez]
AID - 01244665-202103000-00005 [pii]
AID - 10.2459/JCM.0000000000001106 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2021 Mar 1;22(3):180-189. doi: 
      10.2459/JCM.0000000000001106.