PMID- 32891689
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 169
DP  - 2020 Nov
TI  - Reduced minimum rim width of optic nerve head: a potential early marker of 
      retinal neurodegeneration in children and adolescents with type 1 diabetes.
PG  - 108420
LID - S0168-8227(20)30673-2 [pii]
LID - 10.1016/j.diabres.2020.108420 [doi]
AB  - AIMS: To determine whether early retinal neurodegenerative changes in pediatric 
      patients with type 1 diabetes (T1D) can be detected by spectral domain-optical 
      coherence tomography (SD-OCT) and whether such changes are associated with risk 
      factors for T1D complications. METHODS: A total of 147 T1D children/adolescents 
      and 51 healthy controls underwent SD-OCT. Spherical refractive error (SRE), 
      macular total retinal thickness (TRT), ganglion cell layer (GCL), retinal nerve 
      fiber layer (RNFL), minimum rim width (MRW), and Bruch's membrane opening area 
      (BMOA) were measured. Clinical and biochemical parameters were recorded at the 
      time of SD-OCT and starting at T1D onset. Multiple regression models were 
      calculated using SD-OCT parameters as dependent and risk factors as independent 
      variables. RESULTS: MRW was significantly thinner in the T1D patients (global 
      MRW:361.58vs386.33 microm; p = 0.009), while RNFL and macular parameters were similar 
      for both groups. MRW was inversely correlated with mean HbA1c (r >/= -0.180, 
      p < 0.05). Multiple regression showed that part of the variability in MRW was 
      explained by HbA1c and BMOA (R(2) = 0.21; p < 0.001), independent of other 
      cardiometabolic risk factors. CONCLUSIONS: MRW reduction could be a potential 
      early marker of retinal neurodegeneration detectable in pediatric patients with 
      T1D. The association between MRW and mean HbA1c suggests that glucometabolic 
      control may affect early retinal neurodegeneration starting in childhood.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Piona, Claudia
AU  - Piona C
AD  - Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric 
      Diabetes, University City Hospital of Verona, P.le Stefani 1, 37126 Verona, 
      Italy. Electronic address: claudia.piona@univr.it.
FAU - Cozzini, Tiziano
AU  - Cozzini T
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Marchini, Giorgio
AU  - Marchini G
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Merz, Tommaso
AU  - Merz T
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Brighenti, Tommaso
AU  - Brighenti T
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Mazzo, Umberto
AU  - Mazzo U
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Marigliano, Marco
AU  - Marigliano M
AD  - Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric 
      Diabetes, University City Hospital of Verona, P.le Stefani 1, 37126 Verona, 
      Italy.
FAU - Olivieri, Francesca
AU  - Olivieri F
AD  - Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric 
      Diabetes, University City Hospital of Verona, P.le Stefani 1, 37126 Verona, 
      Italy.
FAU - Pedrotti, Emilio
AU  - Pedrotti E
AD  - Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, 
      University of Verona, P.le L. A. Scuro 10, 37134 Verona, Italy.
FAU - Maffeis, Claudio
AU  - Maffeis C
AD  - Pediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric 
      Diabetes, University City Hospital of Verona, P.le Stefani 1, 37126 Verona, 
      Italy. Electronic address: claudio.maffeis@univr.it.
LA  - eng
PT  - Journal Article
DEP - 20200904
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Optic Nerve/*abnormalities
MH  - Retina/*pathology
MH  - Retinal Degeneration/*pathology
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Minimal neuroretinal rim width
OT  - Retinal neurodegeneration
OT  - Spectral domain optical coherence tomography
OT  - Type 1 Diabetes
EDAT- 2020/09/07 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/09/06 20:24
PHST- 2020/07/07 00:00 [received]
PHST- 2020/08/21 00:00 [revised]
PHST- 2020/08/29 00:00 [accepted]
PHST- 2020/09/07 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/09/06 20:24 [entrez]
AID - S0168-8227(20)30673-2 [pii]
AID - 10.1016/j.diabres.2020.108420 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 Nov;169:108420. doi: 10.1016/j.diabres.2020.108420. 
      Epub 2020 Sep 4.