PMID- 32892552
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 49
IP  - 9
DP  - 2020 Sep 8
TI  - [Gastric adenocarcinoma with enteroblastic differentiation and elevated serum 
      alpha fetoprotein].
PG  - 886-890
LID - 10.3760/cma.j.cn112151-20191210-00791 [doi]
AB  - Objective: To study the proportion and clinicopathological characteristics of 
      gastric adenocarcinoma with enteroblastic differentiation (GAED) in gastric 
      cancers showing an elevated serum alpha fetoprotein(AFP). Methods: A total of 724 
      resected gastric adenocarcinomas were collected from 2008 to 2018 at the 904 
      Hospital of Joint Service Support Force, and cases with pre-operative serum 
      AFP>10 mug/L were screened. From the cases with elevated serum AFP, GAED cases 
      were further evaluated based on morphology. Then the clincopathological features 
      and immunohistochemical phenotypes of GAED were reviewed. In addition, the 
      amplification of HER2 gene was detected with fluorescence in situ 
      hybridization(FISH). When overall survival (OS) and progression-free survival 
      (PFS) of GAED were analyzed, 289 cases ordinary gastric adenocarcinoma with 
      normal serum AFP were employed as a control. Results: The percentage of GAED was 
      44% (11/25) in gastric cancers with elevated serum AFP. GAED was histologically 
      tubular or papillary with clear cytoplasm, and some GAED cases showed cystadenoid 
      structure similar to embryo sac (5 cases), homogeneous eosinophilic granules (4 
      cases) and intragland ulareosinophilic material (6 cases). All 11 GAED cases had 
      lymph node metastasis. Liver metastasis and vascular thrombus were observed in 2 
      cases and 5 cases respectively. GAED was immunohistochemically positive for CDX2 
      (11/11), CD10 (8/11) and MUC2(3/11), which were intestinal epithelium 
      differentiation markers. Meanwhile, primitive markers SALL4 (8/11), GPC3 (7/11) 
      and AFP (5/11) were also expressed in GAED, and HER2 gene amplification was found 
      in 3 cases (3/11) of GAED. Lastly, the PFS of GAED were significantly shorter 
      than that of the control group (P=0.02), while OS was not statistically different 
      between these two groups (P=0.99). Conclusions: Patients with GAED usually have a 
      higher rate of elevated serum AFP in gastric adenocarcinoma, and the cancer 
      exhibites features of both intestinal and primitive differentiation. As GAED is 
      highly invasive, the prognosis of GAED may be poor. For GAED, the diagnosis of 
      well-differentiated or moderately-differentiated adenocarcinoma should be 
      avoided, because this diagnosis leads to underestimated malignant potential.
FAU - Li, Q Z
AU  - Li QZ
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Zhao, H B
AU  - Zhao HB
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Ban, N
AU  - Ban N
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Wang, Q
AU  - Wang Q
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Zhang, J J
AU  - Zhang JJ
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Ding, S N
AU  - Ding SN
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Li, H H
AU  - Li HH
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
FAU - Zhou, Z H
AU  - Zhou ZH
AD  - Department of Pathology, the 904 Hospital of Joint Service Support Force, PLA, 
      Jiangsu Province, Wuxi 214044, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (alpha-Fetoproteins)
SB  - IM
MH  - *Adenocarcinoma
MH  - Biomarkers, Tumor
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Stomach Neoplasms
MH  - alpha-Fetoproteins
OTO - NOTNLM
OT  - Enteroblastic differentiation
OT  - Prognosis
OT  - Stomach neoplasms
OT  - alpha-Fetoproteins
EDAT- 2020/09/08 06:00
MHDA- 2020/09/18 06:00
CRDT- 2020/09/07 02:36
PHST- 2020/09/07 02:36 [entrez]
PHST- 2020/09/08 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20191210-00791 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2020 Sep 8;49(9):886-890. doi: 
      10.3760/cma.j.cn112151-20191210-00791.