PMID- 32893669
OWN - NLM
STAT- MEDLINE
DCOM- 20211118
LR  - 20211118
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 99
IP  - 5
DP  - 2021 May
TI  - Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via 
      the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway.
PG  - 468-477
LID - 10.1139/cjpp-2020-0165 [doi]
AB  - Various liver diseases caused by liver damage seriously affect people's health. 
      The purpose of this study was to clarify the effects and the mechanisms of 
      carnitine palmitoyltransferase 1 (Cpt1a) on oxidative stress and inflammation in 
      liver injury. It was found that the expression of Cpt1a mRNA was upregulated in a 
      model of liver injury in mice. Thus, overexpression of Cpt1a increased reactive 
      oxygen species (ROS) production and malondialdehyde (MDA) levels and reduced 
      superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase 
      (GSH-px) levels in an in vitro model of liver injury. It was also shown that 
      overexpression of Cpt1a suppressed the nuclear factor erythroid-2-related 
      factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. In summary, these data 
      indicate that Cpt1a promotes ROS-induced oxidative stress in liver injury via the 
      Nrf2/HO-1 and nucleotide-binding oligomerization domain-like receptor protein 3 
      (NLRP3) inflammasome signaling pathway.
FAU - Luo, Xigang
AU  - Luo X
AD  - Department of Laboratory Medicine, The Third Affiliated Hospital of Jinzhou 
      Medical University, Jinzhou 121000, China.
FAU - Sun, Dapeng
AU  - Sun D
AD  - Department of Clinical Pharmacy, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou 121000, China.
FAU - Wang, Yinxiang
AU  - Wang Y
AD  - Department of Clinical Medicine, Jinzhou Medical University, Jinzhou 121001, 
      China.
FAU - Zhang, Fengxiang
AU  - Zhang F
AD  - Department of Clinical Pharmacy, The First Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou 121000, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Blood Transfusion, The Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou 121000, China.
LA  - eng
PT  - Journal Article
DEP - 20200905
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Inflammasomes)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - *Heme Oxygenase-1
MH  - Inflammasomes/metabolism
MH  - Male
MH  - Mice
MH  - NF-E2-Related Factor 2/metabolism
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - Cpt1a
OT  - Nrf2/HO-1
OT  - ROS
OT  - axe Nrf2/HO-1
OT  - carnitine palmitoyltransferase 1
OT  - derives reactifs de l'oxygene
OT  - inflammasome
OT  - liver injury
OT  - lesions hepatiques
OT  - oxidative stress
OT  - stress oxydatif
EDAT- 2020/09/08 06:00
MHDA- 2021/11/19 06:00
CRDT- 2020/09/07 08:37
PHST- 2020/09/08 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2020/09/07 08:37 [entrez]
AID - 10.1139/cjpp-2020-0165 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2021 May;99(5):468-477. doi: 10.1139/cjpp-2020-0165. 
      Epub 2020 Sep 5.