PMID- 32894413
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211123
IS  - 1559-1174 (Electronic)
IS  - 1535-1084 (Linking)
VI  - 22
IP  - 4
DP  - 2020 Dec
TI  - HLA in Alzheimer's Disease: Genetic Association and Possible Pathogenic Roles.
PG  - 464-473
LID - 10.1007/s12017-020-08612-4 [doi]
AB  - Alzheimer's disease (AD) is commonly considered as the most prominent dementing 
      disorder globally and is characterized by the deposition of misfolded amyloid-beta 
      (Abeta) peptide and the aggregation of neurofibrillary tangles. Immunological 
      disturbances and neuroinflammation, which result from abnormal immunological 
      reactivations, are believed to be the primary stimulating factors triggering 
      AD-like neuropathy. It has been suggested by multiple previous studies that a 
      bunch of AD key influencing factors might be attributed to genes encoding human 
      leukocyte antigen (HLA), whose variety is an essential part of human adaptive 
      immunity. A wide range of activities involved in immune responses may be 
      determined by HLA genes, including inflammation mediated by the immune response, 
      T-cell transendothelial migration, infection, brain development and plasticity in 
      AD pathogenesis, and so on. The goal of this article is to review the recent 
      epidemiological findings of HLA (mainly HLA class I and II) associated with AD 
      and investigate to what extent the genetic variations of HLA were clinically 
      significant as pathogenic factors for AD. Depending on the degree of contribution 
      of HLA in AD pathogenesis, targeted research towards HLA may propel AD 
      therapeutic strategies into a new era of development.
FAU - Wang, Zi-Xuan
AU  - Wang ZX
AUID- ORCID: 0000-0002-4758-8767
AD  - Department of Geriatrics, the Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266071, Shandong Province, China. zixuanwang2013@163.com.
AD  - Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 
      No.308 Ningxia Road, Qingdao, 266071, China. zixuanwang2013@163.com.
FAU - Wan, Qi
AU  - Wan Q
AD  - Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 
      No.308 Ningxia Road, Qingdao, 266071, China. qwanwh@hotmail.com.
AD  - Department of Neurosurgery, Qingdao University, Qingdao, 266071, China. 
      qwanwh@hotmail.com.
AD  - Department of Pathophysiology, Qingdao University, Qingdao, 266071, China. 
      qwanwh@hotmail.com.
FAU - Xing, Ang
AU  - Xing A
AD  - Department of Geriatrics, the Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266071, Shandong Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200907
PL  - United States
TA  - Neuromolecular Med
JT  - Neuromolecular medicine
JID - 101135365
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (invariant chain)
SB  - IM
MH  - Alzheimer Disease/epidemiology/*genetics/immunology/therapy
MH  - Animals
MH  - Antigens, Differentiation, B-Lymphocyte/physiology
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genome-Wide Association Study
MH  - HLA Antigens/*analysis/genetics/immunology/physiology
MH  - Histocompatibility Antigens Class II/physiology
MH  - Humans
MH  - Immunity
MH  - Inflammation
MH  - Microglia/immunology
MH  - Nerve Tissue Proteins/physiology
MH  - Stem Cell Transplantation
MH  - T-Lymphocytes/immunology/physiology
MH  - Transendothelial and Transepithelial Migration
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Genetics
OT  - HLA
OT  - Immune
OT  - Inflammation
OT  - Therapy
EDAT- 2020/09/08 06:00
MHDA- 2021/11/24 06:00
CRDT- 2020/09/07 12:13
PHST- 2019/09/05 00:00 [received]
PHST- 2020/08/29 00:00 [accepted]
PHST- 2020/09/08 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2020/09/07 12:13 [entrez]
AID - 10.1007/s12017-020-08612-4 [pii]
AID - 10.1007/s12017-020-08612-4 [doi]
PST - ppublish
SO  - Neuromolecular Med. 2020 Dec;22(4):464-473. doi: 10.1007/s12017-020-08612-4. Epub 
      2020 Sep 7.