PMID- 32897936
OWN - NLM
STAT- MEDLINE
DCOM- 20210407
LR  - 20211216
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 85
IP  - 5
DP  - 2020 Dec 15
TI  - Brief Report: Time to Repeat Viral Load Testing Among Unsuppressed Adolescents 
      and Young Adults Living With HIV in Kenya.
PG  - 606-611
LID - 10.1097/QAI.0000000000002498 [doi]
AB  - BACKGROUND: Repeat HIV viral load (VL) testing is required after unsuppressed VL 
      to confirm treatment failure. We assessed proportion of adolescents and young 
      adults living with HIV (AYALHIV) in Kenya with a confirmatory VL test and time to 
      repeat testing. DESIGN: A retrospective analysis of longitudinal data abstracted 
      from Kenya's national VL database. METHODS: VL data for AYALHIV who were 10-24 
      year old between April 2017 and May 2019 were abstracted from 117 HIV care 
      clinics. Records were eligible if at least one VL test was performed >/=6 months 
      after antiretroviral therapy (ART) initiation. The proportion of unsuppressed 
      AYALHIV (>/=1000 copies/mL) and time in months between first unsuppressed VL and 
      repeat VL was determined. RESULTS: We abstracted 40,928 VL records for 23,969 
      AYALHIV; of whom, 17,092 (71%) were eligible for this analysis. Of these, 12,122 
      (71%) were women, median age of 19 years [interquartile range (IQR): 13-23], and 
      median ART duration of 38 months (IQR: 16-76). Among eligible AYALHIV, 4010 (23%) 
      had an unsuppressed VL at first eligible measurement. Only 316 (8%) of the 
      unsuppressed AYALHIV had a repeat VL within 3 months and 1176 (29%) within 6 
      months. Among 2311 virally unsuppressed AYALHIV with a repeat VL, the median time 
      between the first and the repeat VL was 6 months (IQR: 4-8), with 1330 (58%) 
      having confirmed treatment failure. CONCLUSIONS: One-quarter of AYALHIV on ART 
      had unsuppressed VL, with less than a third receiving a repeat VL within 6 
      months. Strategies to improve VL testing practices are needed to improve 
      AYALHIV's outcomes.
FAU - Mugo, Cyrus
AU  - Mugo C
AD  - Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
AD  - Departments of Epidemiology; and.
FAU - Wilson, Katherine S
AU  - Wilson KS
AD  - Global Health, University of Washington, Seattle, WA.
FAU - Onyango, Alvin
AU  - Onyango A
AD  - Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
FAU - Njuguna, Irene N
AU  - Njuguna IN
AD  - Global Health, University of Washington, Seattle, WA.
FAU - Mburu, Caren W
AU  - Mburu CW
AD  - Global Health, University of Washington, Seattle, WA.
FAU - Richardson, Barbra A
AU  - Richardson BA
AD  - Global Health, University of Washington, Seattle, WA.
AD  - Department of Biostatistics, University of Washington, Seattle, WA.
FAU - Oyiengo, Laura
AU  - Oyiengo L
AD  - National AIDS and STI Control Programme, Ministry of Health, Nairobi, Kenya.
FAU - Inwani, Irene
AU  - Inwani I
AD  - Department of Pediatrics, Kenyatta National Hospital, Nairobi, Kenya; and.
FAU - John-Stewart, Grace
AU  - John-Stewart G
AD  - Departments of Epidemiology; and.
AD  - Global Health, University of Washington, Seattle, WA.
AD  - Departments of Medicine.
AD  - Pediatrics; and.
FAU - Wamalwa, Dalton C
AU  - Wamalwa DC
AD  - Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
FAU - Kohler, Pamela K
AU  - Kohler PK
AD  - Global Health, University of Washington, Seattle, WA.
AD  - Child, Family, and Population Health Nursing, University of Washington, Seattle, 
      WA.
LA  - eng
GR  - D43 TW009783/TW/FIC NIH HHS/United States
GR  - R01 HD085807/HD/NICHD NIH HHS/United States
GR  - R01 HD089850/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anti-HIV Agents/therapeutic use
MH  - Child
MH  - Female
MH  - HIV Infections/drug therapy/*virology
MH  - Humans
MH  - Kenya
MH  - Male
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Failure
MH  - *Viral Load/statistics & numerical data
MH  - Young Adult
PMC - PMC8559766
MID - NIHMS1750257
EDAT- 2020/09/09 06:00
MHDA- 2021/04/10 06:00
PMCR- 2021/12/15
CRDT- 2020/09/08 17:11
PHST- 2020/09/09 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/09/08 17:11 [entrez]
PHST- 2021/12/15 00:00 [pmc-release]
AID - 00126334-202012150-00014 [pii]
AID - 10.1097/QAI.0000000000002498 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2020 Dec 15;85(5):606-611. doi: 
      10.1097/QAI.0000000000002498.