PMID- 32899412
OWN - NLM
STAT- MEDLINE
DCOM- 20210331
LR  - 20240210
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 11
IP  - 9
DP  - 2020 Sep 3
TI  - The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.
LID - 10.3390/genes11091043 [doi]
LID - 1043
AB  - Ageing is a complex trait controlled by genes and the environment. The highly 
      conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major 
      regulator of lifespan in all eukaryotes and is thought to be mediating some of 
      the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse 
      inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan 
      by tuning cellular functions such as gene expression, ribosome biogenesis, 
      proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling 
      pathway is implicated in multiple age-related diseases such as cancer, 
      neurodegeneration, and auto-immunity. In this review, we briefly summarise some 
      of the workings of mTOR in lifespan and ageing through the processes of 
      transcription, translation, autophagy, and metabolism. A good understanding of 
      the pathway's outputs and connectivity is paramount towards our ability for 
      genetic and pharmacological interventions for healthy ageing and amelioration of 
      age-related disease.
FAU - Bjedov, Ivana
AU  - Bjedov I
AD  - UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, 
      UK.
FAU - Rallis, Charalampos
AU  - Rallis C
AUID- ORCID: 0000-0002-4390-0266
AD  - School of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, 
      UK.
LA  - eng
GR  - 28990/CRUK_/Cancer Research UK/United Kingdom
GR  - MR/M02492X/1/MRC_/Medical Research Council/United Kingdom
GR  - C416/A25145/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200903
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aging/metabolism/*pathology
MH  - Animals
MH  - *Autophagy
MH  - Humans
MH  - *Longevity
MH  - Signal Transduction
MH  - Sirolimus/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC7565554
OTO - NOTNLM
OT  - Drosophila
OT  - TORC1
OT  - TORC2
OT  - ageing
OT  - autophagy
OT  - metabolism
OT  - nutrient-response
OT  - transcription
OT  - translation
OT  - yeast
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/10 06:00
MHDA- 2021/04/01 06:00
PMCR- 2020/09/01
CRDT- 2020/09/09 01:03
PHST- 2020/08/18 00:00 [received]
PHST- 2020/08/28 00:00 [revised]
PHST- 2020/08/30 00:00 [accepted]
PHST- 2020/09/09 01:03 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2021/04/01 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - genes11091043 [pii]
AID - genes-11-01043 [pii]
AID - 10.3390/genes11091043 [doi]
PST - epublish
SO  - Genes (Basel). 2020 Sep 3;11(9):1043. doi: 10.3390/genes11091043.