PMID- 32899766
OWN - NLM
STAT- MEDLINE
DCOM- 20210309
LR  - 20210309
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 18
DP  - 2020 Sep 4
TI  - Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) 
      on Rodent Models of Allergic Rhinitis and Asthma.
LID - 10.3390/molecules25184051 [doi]
LID - 4051
AB  - Allergic rhinitis and asthma are common chronic allergic diseases of the 
      respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated 
      inflammation and the involvement of type 2 T helper cells, mast cells, and 
      eosinophils. Cordyceps sinensis (Berk.) Sacc is a fungal parasite on the larva of 
      Lepidoptera. It has been considered to be a health-promoting food and, also, one 
      of the best-known herbal remedies for the treatment of airway diseases, such as 
      asthma and lung inflammation. In the present study, we demonstrated the 
      antiallergic rhinitis effect of Cs-4, a water extract prepared from the mycelium 
      culture of Cordyceps sinensis (Berk) Sacc, on ovalbumin (OVA)-induced allergic 
      rhinitis in mice and the anti-asthmatic effect of Cs-4 in a rat model of asthma. 
      Treatment with Cs-4 suppressed the nasal symptoms induced in OVA-sensitized and 
      challenged mice. The inhibition was associated with a reduction in IgE/OVA-IgE 
      and interleukin (IL)-4/IL-13 levels in the nasal fluid. Cs-4 treatment also 
      decreased airway responsiveness and ameliorated the scratching behavior in 
      capsaicin-challenged rats. It also reduced plasma IgE levels, as well as IgE and 
      eosinophil peroxidase levels, in the bronchoalveolar fluid. Cs-4 treatment 
      completely suppressed the increases in IL-4, IL-5, and IL-13 levels in rat lung 
      tissue. In conclusion, our results suggest that Cs-4 has the potential to 
      alleviate immune hypersensitivity reactions in allergic rhinitis and asthma.
FAU - Chen, Jihang
AU  - Chen J
AD  - School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 
      518172, China.
FAU - Chan, Wing Man
AU  - Chan WM
AD  - Division of Life Science, The Hong Kong University of Science & Technology, Clear 
      Water Bay, Hong Kong SAR 999077, China.
FAU - Leung, Hoi Yan
AU  - Leung HY
AD  - Division of Life Science, The Hong Kong University of Science & Technology, Clear 
      Water Bay, Hong Kong SAR 999077, China.
FAU - Leong, Pou Kuan
AU  - Leong PK
AD  - Division of Life Science, The Hong Kong University of Science & Technology, Clear 
      Water Bay, Hong Kong SAR 999077, China.
FAU - Yan, Choly Tat Ming
AU  - Yan CTM
AD  - Royal Medic Group Holding Limited, 313 Castle Peak Road, Hong Kong SAR 999077, 
      China.
FAU - Ko, Kam Ming
AU  - Ko KM
AD  - Division of Life Science, The Hong Kong University of Science & Technology, Clear 
      Water Bay, Hong Kong SAR 999077, China.
LA  - eng
GR  - 17181310CCLX07K003/Royal Medic Group Holding Limited/
PT  - Journal Article
DEP - 20200904
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.11.1.- (Eosinophil Peroxidase)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Asthma/blood/complications/*drug therapy/physiopathology
MH  - Body Weight/drug effects
MH  - Bronchi/drug effects
MH  - Bronchial Hyperreactivity/blood/complications/drug therapy/physiopathology
MH  - Bronchoalveolar Lavage Fluid
MH  - Capsaicin/pharmacology
MH  - Cordyceps/*chemistry
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Eosinophil Peroxidase/metabolism
MH  - Female
MH  - Histamine Release/drug effects
MH  - Immunization
MH  - Immunoglobulin E/blood
MH  - Mast Cells/drug effects/metabolism
MH  - Methacholine Chloride/pharmacology
MH  - Mice, Inbred BALB C
MH  - Mycelium/*chemistry
MH  - Nasal Lavage
MH  - Ovalbumin/immunology
MH  - Rats, Sprague-Dawley
MH  - Rhinitis, Allergic/blood/complications/*drug therapy
MH  - Skin/drug effects/pathology
MH  - Spleen/drug effects/pathology
MH  - Trachea/drug effects
MH  - beta-N-Acetylhexosaminidases/metabolism
PMC - PMC7570676
OTO - NOTNLM
OT  - Cordyceps
OT  - allergic rhinitis
OT  - anti-inflammatory effect
OT  - asthma
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/10 06:00
MHDA- 2021/03/10 06:00
PMCR- 2020/09/04
CRDT- 2020/09/09 01:04
PHST- 2020/08/04 00:00 [received]
PHST- 2020/09/02 00:00 [revised]
PHST- 2020/09/02 00:00 [accepted]
PHST- 2020/09/09 01:04 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2021/03/10 06:00 [medline]
PHST- 2020/09/04 00:00 [pmc-release]
AID - molecules25184051 [pii]
AID - molecules-25-04051 [pii]
AID - 10.3390/molecules25184051 [doi]
PST - epublish
SO  - Molecules. 2020 Sep 4;25(18):4051. doi: 10.3390/molecules25184051.