PMID- 32899835 OWN - NLM STAT- MEDLINE DCOM- 20200922 LR - 20201218 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 17 IP - 18 DP - 2020 Sep 4 TI - Resilience Moderates Negative Outcome from Stress during the COVID-19 Pandemic: A Moderated-Mediation Approach. LID - 10.3390/ijerph17186461 [doi] LID - 6461 AB - Resilience refers to an individual's healthy coping abilities when encountering adverse life events. The COVID-19 pandemic represents a situation with a high amount of stress exposure, which in turn may be associated with negative emotional outcome like depressive symptoms. The current study investigated if resilience moderated the effect of stress on symptoms of depression and if anxiety symptoms mediated this association. An adult sample of community controls completed the Perceived stress scale 14 (PSS-14), the Resilience scale for adults (RSA), the Patient health questionnaire 9 (PHQ-9) and the Generalized anxiety disorder 7 (GAD-7). Independent samples t-test, correlation analyses and moderated mediation analyses were conducted. The results showed that resilience moderated the relations between stress and anxiety symptoms (beta = -0.131, p < 0.001) as well as between stress and depressive symptoms (beta = -0.068, p < 0.05). In support of a moderated mediation model, resilience moderated the indirect effect of stress on depressive symptom, as confirmed by the index of moderated mediation (IMM = -0.036, p < 0.001; [95% BCa: -0.055, -0.020]). The high resilience subgroup was less affected than the low resilience subgroup by the effect of stress exposure symptoms of depression, mediated by anxiety. The study shows that stress exposure is associated with symptoms of depression, and anxiety mediates this association. Level of resilience differentiates the direct and indirect effect of stress on depression. Knowledge about the effect of stress in response to a pandemic is important for developing treatment and prevention strategies for stress, depression and health-related anxiety. FAU - Havnen, Audun AU - Havnen A AD - Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway. FAU - Anyan, Frederick AU - Anyan F AUID- ORCID: 0000-0002-0339-3263 AD - Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway. FAU - Hjemdal, Odin AU - Hjemdal O AD - Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway. FAU - Solem, Stian AU - Solem S AD - Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway. FAU - Gurigard Riksfjord, Maja AU - Gurigard Riksfjord M AUID- ORCID: 0000-0003-1294-9777 AD - Molde Hospital, More og Romsdal Hospital Trust, 6412 Molde, Norway. FAU - Hagen, Kristen AU - Hagen K AUID- ORCID: 0000-0002-4286-1277 AD - Molde Hospital, More og Romsdal Hospital Trust, 6412 Molde, Norway. AD - Department of Mental Health, Norwegian University of Science and Technology, 7491 Trondheim, Norway. LA - eng PT - Journal Article DEP - 20200904 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adult MH - Anxiety/*epidemiology MH - Betacoronavirus MH - COVID-19 MH - Coronavirus Infections/*psychology MH - Cross-Sectional Studies MH - Depression/*epidemiology MH - Humans MH - Pandemics MH - Pneumonia, Viral/*psychology MH - *Resilience, Psychological MH - SARS-CoV-2 MH - Stress, Psychological/epidemiology MH - Surveys and Questionnaires PMC - PMC7558712 OTO - NOTNLM OT - anxiety OT - depression OT - moderated mediation OT - resilience OT - stress COIS- The authors declare no conflict of interest. EDAT- 2020/09/10 06:00 MHDA- 2020/09/23 06:00 PMCR- 2020/09/01 CRDT- 2020/09/09 01:04 PHST- 2020/07/18 00:00 [received] PHST- 2020/08/28 00:00 [revised] PHST- 2020/09/02 00:00 [accepted] PHST- 2020/09/09 01:04 [entrez] PHST- 2020/09/10 06:00 [pubmed] PHST- 2020/09/23 06:00 [medline] PHST- 2020/09/01 00:00 [pmc-release] AID - ijerph17186461 [pii] AID - ijerph-17-06461 [pii] AID - 10.3390/ijerph17186461 [doi] PST - epublish SO - Int J Environ Res Public Health. 2020 Sep 4;17(18):6461. doi: 10.3390/ijerph17186461.