PMID- 32900985
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 45
IP  - 12
DP  - 2020 Dec
TI  - Is the minimal clinically important difference (MCID) in acute pain a good 
      measure of analgesic efficacy in regional anesthesia?
PG  - 1000-1005
LID - 10.1136/rapm-2020-101670 [doi]
AB  - In the field of acute pain medicine research, we believe there is an unmet need 
      to incorporate patient related outcome measures that move beyond reporting pain 
      scores and opioid consumption. The term "minimal clinically important difference" 
      (MCID) defines the clinical benefit of an intervention as perceived by the 
      patient, as opposed to a mathematically determined statistically significant 
      difference that may not necessarily be clinically significant. The present 
      article reviews the concept of MCID in acute postoperative pain research, 
      addresses potential pitfalls in MCID determination and questions the clinical 
      validity of extrapolating MCID determined from chronic pain and non-surgical pain 
      studies to the acute postoperative pain setting. We further suggest the concepts 
      of minimal clinically important improvement, substantial clinical benefit and 
      patient acceptable symptom state should also represent aspirational outcomes for 
      future research in acute postoperative pain management.
CI  - (c) American Society of Regional Anesthesia & Pain Medicine 2020. No commercial 
      re-use. See rights and permissions. Published by BMJ.
FAU - Munoz-Leyva, Felipe
AU  - Munoz-Leyva F
AUID- ORCID: 0000-0001-8989-1580
AD  - Department of Anesthesia & Pain Management, University Health Network, University 
      of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
FAU - El-Boghdadly, Kariem
AU  - El-Boghdadly K
AUID- ORCID: 0000-0002-9912-717X
AD  - Department of Anaesthesia and Perioperative Medicine, Guy's and St Thomas' NHS 
      Foundation Trust, London, UK.
AD  - King's College London, London, United Kingdom.
FAU - Chan, Vincent
AU  - Chan V
AD  - Department of Anesthesia & Pain Management, University Health Network, University 
      of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada 
      mail2vincechan@aol.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200907
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
RN  - 0 (Analgesics)
SB  - IM
MH  - *Acute Pain/diagnosis/drug therapy
MH  - Analgesics
MH  - *Anesthesia, Conduction
MH  - Humans
MH  - Minimal Clinically Important Difference
MH  - Pain, Postoperative/diagnosis/prevention & control
MH  - Treatment Outcome
OTO - NOTNLM
OT  - analgesia
OT  - pain
OT  - pain measurement
OT  - pain perception
OT  - postoperative
OT  - regional anesthesia
COIS- Competing interests: None declared.
EDAT- 2020/09/10 06:00
MHDA- 2021/07/20 06:00
CRDT- 2020/09/09 05:26
PHST- 2020/05/05 00:00 [received]
PHST- 2020/07/26 00:00 [revised]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2020/09/09 05:26 [entrez]
AID - rapm-2020-101670 [pii]
AID - 10.1136/rapm-2020-101670 [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2020 Dec;45(12):1000-1005. doi: 10.1136/rapm-2020-101670. 
      Epub 2020 Sep 7.