PMID- 32902742
OWN - NLM
STAT- MEDLINE
DCOM- 20210602
LR  - 20220119
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 45
IP  - 11
DP  - 2020 Nov
TI  - Effect of Early Normobaric Hyperoxia on Blast-Induced Traumatic Brain Injury in 
      Rats.
PG  - 2723-2731
LID - 10.1007/s11064-020-03123-x [doi]
AB  - Blast-induced traumatic brain injury (bTBI) is a leading cause of disability and 
      mortality in soldiers during the conflicts in Iraq and Afghanistan. Although 
      substantial clinical and animal studies have investigated the pathophysiology and 
      treatments of bTBI, few effective therapies have been found, especially for the 
      early rescue in the battlefield. The aim of this study is to evaluate 
      neuroprotective effects of early normobaric hyperoxia (NBO) on bTBI. We 
      established a rat model of bTBI caused by explosion in the cabin. It exhibited 
      typical changes of mild bTBI, like impaired neurological function, brain edema, 
      minor intracranial hemorrhage and neuron necrosis. The rats were divided into 4 
      groups (n = 12): Sham, Vehicle, hyperbaric oxygen (HBO) and NBO. Neurological 
      function of the rats was assessed by the Neurological Severity Scores (NSS) at 
      24 h and 72 h after explosion. Serum interleukin-6 (IL-6), neuron specific 
      enolase (NSE) and tau protein were measured at 24 h and 72 h after explosion. 
      Brain water content was measured and Aquaporin-4 (AQP4) immunostaining was 
      performed. Neuronal apoptosis was analyzed by TUNEL staining. NBO demonstrated 
      curative effects on protecting the neurological function. Serum levels of 
      NSE and tau protein were reduced at 24 h and 72 h after explosion. But the levels 
      of IL-6 were not reduced significantly at both time points. Cerebral edema was 
      alleviated. Simultaneously, AQP4 immunostaining of the hippocampus showed 
      remarkably decreased expression after treatment. The number of apoptotic cells in 
      hippocampus was also decreased. Compared with HBO, NBO is simple and convenient, 
      and can be administered in remote areas. It may be a promising therapy for early 
      rescue of bTBI in the battlefield.
FAU - Li, Yanteng
AU  - Li Y
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Lv, Wenying
AU  - Lv W
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Cheng, Gang
AU  - Cheng G
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Wang, Shuwei
AU  - Wang S
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Liu, Bangxin
AU  - Liu B
AD  - Department of Neurosurgery, Central War Zone General Hospital of PLA, Wuhan, 
      430070, China.
FAU - Zhao, Hulin
AU  - Zhao H
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Wang, Hongwei
AU  - Wang H
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Zhang, Leiming
AU  - Zhang L
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Dong, Chao
AU  - Dong C
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.
FAU - Zhang, Jianning
AU  - Zhang J
AUID- ORCID: 0000-0002-1784-802X
AD  - Department of Neurosurgery, Sixth Medical Center, Chinese PLA General Hospital, 
      No. 6, Fucheng Road, Haidian District, Beijing, 100048, China. 
      jianningzhang2008@163.com.
LA  - eng
GR  - AHJ14J001/Major Projects of PLA Logistics/
GR  - 81372128/Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200909
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Aqp4 protein, rat)
RN  - 0 (Aquaporin 4)
RN  - 0 (Il6 protein, rat)
RN  - 0 (Interleukin-6)
RN  - 0 (Mapt protein, rat)
RN  - 0 (tau Proteins)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Aquaporin 4/metabolism
MH  - Blast Injuries/*therapy
MH  - Brain Injuries, Traumatic/*therapy
MH  - Explosions
MH  - Hippocampus/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Neuroprotection/*physiology
MH  - Oxygen/*therapeutic use
MH  - *Oxygen Inhalation Therapy
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Rats, Sprague-Dawley
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - Blast injuries
OT  - Brain edema
OT  - Brain injuries
OT  - Normobaric hyperoxia
OT  - Rat
EDAT- 2020/09/10 06:00
MHDA- 2021/06/03 06:00
CRDT- 2020/09/09 12:33
PHST- 2020/04/16 00:00 [received]
PHST- 2020/09/03 00:00 [accepted]
PHST- 2020/07/28 00:00 [revised]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2021/06/03 06:00 [medline]
PHST- 2020/09/09 12:33 [entrez]
AID - 10.1007/s11064-020-03123-x [pii]
AID - 10.1007/s11064-020-03123-x [doi]
PST - ppublish
SO  - Neurochem Res. 2020 Nov;45(11):2723-2731. doi: 10.1007/s11064-020-03123-x. Epub 
      2020 Sep 9.