PMID- 32903659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Association Between Cognitive Function and Early Life Experiences in Patients 
      with Alcohol Use Disorder.
PG  - 792
LID - 10.3389/fpsyt.2020.00792 [doi]
LID - 792
AB  - INTRODUCTION: Early life experiences could be potential risk factors for the 
      development of alcohol use disorder. In similar circumstances, it might also 
      influence cognitive impairment in later life. However, the relationship between 
      early life experience and cognitive function in people with alcohol use disorders 
      is unclear. The current study examined the effects of early social environments 
      and experiences on cognitive function in patients with alcohol use disorder. 
      METHODS: A total of 37 adult male patients with alcohol use disorder and 30 
      healthy control (HC) subjects were enrolled. The MATRICS Cognitive Consensus 
      Battery (MCCB) was used to evaluate cognitive function. The Childhood Trauma 
      Questionnaire (CTQ) and the Revised Adult Attachment Scale (RAAS) were used to 
      evaluate early life experiences of the participants. The RAAS was used to 
      evaluate the attachment patterns of participants. RESULTS: Compared with the HC 
      group, the alcohol use disorder group reported higher levels of childhood abuse 
      and were more likely to form an insecure attachment style. Patients with alcohol 
      use disorder who experienced trauma performed worse in terms of discrete 
      cognitive parameters such as social cognition, reasoning and problem solving 
      compared to patients without trauma. Importantly, emotional neglect and social 
      comfort were significantly associated with individual social cognitive skills. 
      CONCLUSIONS: Our results suggest that the cognitive function of patients with 
      alcohol use disorder, especially social cognitive function, is affected by early 
      life experiences.
CI  - Copyright (c) 2020 Cheng, Cui, Zhang, Zhang, Wang, Yuan, Huang, Zhang and Zhou.
FAU - Cheng, Fangshuo
AU  - Cheng F
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Cui, Shu
AU  - Cui S
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Pediatrics, Fuyang People's Hospital, Fuyang, China.
FAU - Zhang, Ling
AU  - Zhang L
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Yuan, Qiuyu
AU  - Yuan Q
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Huang, Cui
AU  - Huang C
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Zhang, Kai
AU  - Zhang K
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
FAU - Zhou, Xiaoqin
AU  - Zhou X
AD  - Department of Psychiatry, Chaohu Hospital, Anhui Medical University, Hefei, 
      China.
AD  - Anhui Psychiatric Center, Anhui Medical University, Hefei, China.
LA  - eng
PT  - Journal Article
DEP - 20200813
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7438706
OTO - NOTNLM
OT  - alcohol use disorder
OT  - attachment
OT  - cognitive function
OT  - early life experiences
OT  - social cognitive function
EDAT- 2020/09/10 06:00
MHDA- 2020/09/10 06:01
PMCR- 2020/08/13
CRDT- 2020/09/09 17:56
PHST- 2020/07/01 00:00 [received]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/09/09 17:56 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/09/10 06:01 [medline]
PHST- 2020/08/13 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.00792 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 Aug 13;11:792. doi: 10.3389/fpsyt.2020.00792. eCollection 
      2020.