PMID- 32904430
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210610
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 32
DP  - 2020 Oct
TI  - Transcriptomic data from the rat liver after five days of exposure to legacy or 
      emerging brominated flame retardants.
PG  - 106136
LID - 10.1016/j.dib.2020.106136 [doi]
LID - 106136
AB  - Large-scale gene expression analysis of legacy* and emerging** brominated flame 
      retardants were conducted in the male Harlan Sprague Dawley rat [1]. Each animal 
      was dosed for 5 days with the chemical at concentrations of 0.1 - 1000 mumol/kg 
      body weight per day. Following the last dose, a specimen of the left liver was 
      removed for RNA extraction. The amplified RNA (aRNA) was fragmented and then 
      hybridized to Affymetrix Rat Genome 230 2.0 Arrays. Each GeneChip(R) array was 
      scanned using an Affymetrix GeneChip(R) Scanner 3000 7 G to generate raw expression 
      level data (.CEL files). Statistical contrasts were used to find pairwise gene 
      expression differences between the control group and each dose group using the 
      R/maanova package [2]. The transcriptomic data can be used to provide insights 
      into the degree of toxicity, toxic mechanisms, disease pathways activated by 
      exposure, and for benchmark dose analysis. The gene expression data for each of 
      the nine flame retardants discussed here accompanies the research article 
      entitled, "Comparative Toxicity and Liver Transcriptomics of Legacy and Emerging 
      Brominated Flame Retardants following 5-Day Exposure in the Rat" [1]. * 
      polybrominated diphenyl ether 47 (PBDE 47), decabromodiphenyl ether (decaBDE), 
      hexabromocyclododecane (HBCD); ** 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB); 
      bis(2-ethylhexyl) tetrabromophthalate (TBPH); tetrabromobisphenol 
      A-bis(2,3-dibromopropyl ether (TBBPA-DBPE); 1,2-bis(tribromophenoxy)ethane 
      (BTBPE); decabromodiphenylethane (DBDPE); 
      hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO).
FAU - Shockley, Keith R
AU  - Shockley KR
AD  - Biostatistics & Computational Biology Branch, Division of Intramural Research, 
      National Institute of Environmental Health Sciences (NIEHS), Research Triangle 
      Park, NC 27709, United States.
FAU - Cora, Michelle C
AU  - Cora MC
AD  - Cellular & Molecular Pathology Branch, Division of the National Toxicology 
      Program (DNTP), NIEHS, Research Triangle Park, NC 27709, United States.
FAU - Malarkey, David E
AU  - Malarkey DE
AD  - Cellular & Molecular Pathology Branch, Division of the National Toxicology 
      Program (DNTP), NIEHS, Research Triangle Park, NC 27709, United States.
FAU - Jackson-Humbles, Daven
AU  - Jackson-Humbles D
AD  - Cellular & Molecular Pathology Branch, Division of the National Toxicology 
      Program (DNTP), NIEHS, Research Triangle Park, NC 27709, United States.
FAU - Vallant, Molly
AU  - Vallant M
AD  - Program Operations Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United 
      States.
FAU - Collins, Brad J
AU  - Collins BJ
AD  - Program Operations Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United 
      States.
FAU - Mutlu, Esra
AU  - Mutlu E
AD  - Program Operations Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United 
      States.
FAU - Robinson, Veronica G
AU  - Robinson VG
AD  - Program Operations Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United 
      States.
FAU - Waidyanatha, Surayma
AU  - Waidyanatha S
AD  - Program Operations Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United 
      States.
FAU - Zmarowski, Amy
AU  - Zmarowski A
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Machesky, Nicholas
AU  - Machesky N
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Richey, Jamie
AU  - Richey J
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Harbo, Sam
AU  - Harbo S
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Cheng, Emily
AU  - Cheng E
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Patton, Kristin
AU  - Patton K
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Sparrow, Barney
AU  - Sparrow B
AD  - Battelle, Columbus, Ohio 43210, United States.
FAU - Dunnick, June K
AU  - Dunnick JK
AD  - Toxicology Branch, DNTP, NIEHS, Research Triangle Park, NC 27709, United States.
LA  - eng
GR  - HHSN273201400015C/ES/NIEHS NIH HHS/United States
GR  - ZIA ES103166/ImNIH/Intramural NIH HHS/United States
GR  - HHSN273201400022C/ES/NIEHS NIH HHS/United States
GR  - HHSN273201400027C/ES/NIEHS NIH HHS/United States
GR  - ZIA ES103316/ImNIH/Intramural NIH HHS/United States
GR  - HHSN273201400020C/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20200805
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC7452714
OTO - NOTNLM
OT  - 5-Day toxicogenomic studies
OT  - Genomic benchmark dose analysis
OT  - Liver toxicity
OT  - Toxicity of legacy and emerging brominated flame retardants
COIS- All of the authors declare that they have no known competing financial interests 
      or personal relationships which have, or could be perceived to have, influenced 
      the work reported in this article.
EDAT- 2020/09/10 06:00
MHDA- 2020/09/10 06:01
PMCR- 2020/08/05
CRDT- 2020/09/09 18:04
PHST- 2020/07/15 00:00 [received]
PHST- 2020/07/28 00:00 [revised]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/09/09 18:04 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/09/10 06:01 [medline]
PHST- 2020/08/05 00:00 [pmc-release]
AID - S2352-3409(20)31030-1 [pii]
AID - 106136 [pii]
AID - 10.1016/j.dib.2020.106136 [doi]
PST - epublish
SO  - Data Brief. 2020 Aug 5;32:106136. doi: 10.1016/j.dib.2020.106136. eCollection 
      2020 Oct.