PMID- 32904815
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210303
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 8
IP  - 9
DP  - 2020 Sep
TI  - Patency of endoscopic ultrasound-guided gastroenterostomy in the treatment of 
      malignant gastric outlet obstruction.
PG  - E1194-E1201
LID - 10.1055/a-1214-5659 [doi]
AB  - Background and study aims  Endoscopic ultrasound-guided gastroenterostomy 
      (EUS-GE) with a lumen-apposing metal stent (LAMS) is a novel, minimally invasive 
      technique in the palliative treatment of malignant gastric outlet obstruction 
      (GOO). Several studies have demonstrated feasibility and safety of EUS-GE, but 
      evidence on long-term durability is limited. The aim of this study was to 
      evaluate patency of EUS-GE in treatment of malignant GOO. Patients and Methods  
      An international multicenter study was performed in seven centers in four 
      European countries. Patients who underwent EUS-GE with a LAMS between March 2015 
      and March 2019 for palliative treatment of symptomatic malignant GOO were 
      included retrospectively. Our main outcome was recurrent obstruction due to LAMS 
      dysfunction; other outcomes of interest were technical success, clinical success, 
      adverse events (AEs), and survival. Results  A total of 45 patients (mean age 
      69.9 +/- 12.3 years and 48.9 % male) were included. Median duration of follow-up 
      was 59 days (interquartile range [IQR] 41-128). Recurrent obstruction occurred in 
      two patients (6.1 %), after 33 and 283 days of follow-up. Technical success was 
      achieved in 39 patients (86.7 %). Clinical success was achieved in 33 patients 
      (73.3 %). AEs occurred in 12 patients (26.7 %), of which five were fatal. Median 
      overall survival was 57 days (IQR 32-114). Conclusions  EUS-GE showed a low rate 
      of recurrent obstruction. The relatively high number of fatal AEs underscores the 
      importance of careful implementation of EUS-GE in clinical practice.
FAU - Kastelijn, Janine B
AU  - Kastelijn JB
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Moons, Leon M G
AU  - Moons LMG
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Garcia-Alonso, Francisco J
AU  - Garcia-Alonso FJ
AD  - Department of Gastroenterology and Hepatology, Hospital Universitario Rio 
      Hortega, Valladolid, Spain.
FAU - Perez-Miranda, Manuel
AU  - Perez-Miranda M
AD  - Department of Gastroenterology and Hepatology, Hospital Universitario Rio 
      Hortega, Valladolid, Spain.
FAU - Masaryk, Viliam
AU  - Masaryk V
AD  - Department of Gastroenterology and General Internal Medicine, SRH Wald-Klinikum, 
      Gera, Germany.
FAU - Will, Uwe
AU  - Will U
AD  - Department of Gastroenterology and General Internal Medicine, SRH Wald-Klinikum, 
      Gera, Germany.
FAU - Tarantino, Ilaria
AU  - Tarantino I
AD  - Gastroenterology and Endoscopy Unit, Mediterranean Institute for Transplantation 
      and Advanced Specialized Therapies (IsMeTT), Palermo, Italy.
FAU - van Dullemen, Hendrik M
AU  - van Dullemen HM
AD  - Department of Gastroenterology and Hepatology, University Medical Center 
      Groningen, Groningen, The Netherlands.
FAU - Bijlsma, Rina
AU  - Bijlsma R
AD  - Department of Gastroenterology and Hepatology, Martini Hospital Groningen, 
      Groningen, The Netherlands.
FAU - Poley, Jan-Werner
AU  - Poley JW
AD  - Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 
      Rotterdam, The Netherlands.
FAU - Schwartz, Matthijs P
AU  - Schwartz MP
AD  - Department of Gastroenterology and Hepatology, Meander Medical Center, 
      Amersfoort, The Netherlands.
FAU - Vleggaar, Frank P
AU  - Vleggaar FP
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200831
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
CIN - Endosc Int Open. 2020 Oct;8(10):E1455-E1457. PMID: 33043113
CIN - Endosc Int Open. 2021 Mar;9(3):E421-E422. PMID: 33655044
PMC - PMC7458745
COIS- Competing interests Dr. Moons, Drs. Masaryk, Dr. Will, Dr. Poley, and Dr. 
      Vleggaar are consultants for Boston Scientific. Dr. Poley is also a consultant 
      for Cook and Pentax. Dr. Perez-Miranda is a consultant for MITech and Boston 
      Scientific, and speaker for Boston Scientific, MITech, Olympus, and Taewoong.
EDAT- 2020/09/10 06:00
MHDA- 2020/09/10 06:01
PMCR- 2020/09/01
CRDT- 2020/09/09 18:08
PHST- 2020/02/25 00:00 [received]
PHST- 2020/05/28 00:00 [accepted]
PHST- 2020/09/09 18:08 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/09/10 06:01 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - 10.1055/a-1214-5659 [doi]
PST - ppublish
SO  - Endosc Int Open. 2020 Sep;8(9):E1194-E1201. doi: 10.1055/a-1214-5659. Epub 2020 
      Aug 31.