PMID- 32905008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 2632-7376 (Electronic)
IS  - 2632-7376 (Linking)
VI  - 1
IP  - 1
DP  - 2020
TI  - Hippocampal Resting-State Functional Connectivity Patterns are More Closely 
      Associated with Severity of Subjective Memory Decline than Whole Hippocampal and 
      Subfield Volumes.
PG  - tgaa019
LID - 10.1093/texcom/tgaa019 [doi]
LID - tgaa019
AB  - The goal of this study was to examine whether hippocampal volume or resting-state 
      functional connectivity (rsFC) patterns are associated with subjective memory 
      decline (SMD) in cognitively normal aged adults. Magnetic resonance imaging data 
      from 53 participants (mean age: 71.9 years) of the Boston University Alzheimer's 
      Disease Center registry were used in this cross-sectional study. Separate 
      analyses treating SMD as a binary and continuous variable were performed. 
      Subfield volumes were generated using FreeSurfer v6.0, and rsFC strength between 
      the head and body of the hippocampus and the rest of the brain was calculated. 
      Decreased left whole hippocampal volume and weaker rsFC strength between the 
      right body of the hippocampus and the default mode network (DMN) were found in 
      SMD+. Cognitive Change Index score was not correlated with volumetric measures 
      but was inversely correlated with rsFC strength between the right body of the 
      hippocampus and 6 brain networks, including the DMN, task control, and 
      attentional networks. These findings suggest that hippocampal rsFC patterns 
      reflect the current state of SMD in cognitively normal adults and may reflect 
      subtle memory changes that standard neuropsychological tests are unable to 
      capture.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Zajac, Lauren
AU  - Zajac L
AD  - Department of Anatomy & Neurobiology, Boston University School of Medicine, 
      Boston, MA 02118, USA.
FAU - Koo, Bang-Bon
AU  - Koo BB
AD  - Department of Anatomy & Neurobiology, Boston University School of Medicine, 
      Boston, MA 02118, USA.
FAU - Tripodis, Yorghos
AU  - Tripodis Y
AD  - Boston University Alzheimer's Disease Center, Boston University School of 
      Medicine, Boston, MA 02118, USA.
FAU - Mian, Asim
AU  - Mian A
AD  - Department of Radiology, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Steinberg, Eric
AU  - Steinberg E
AD  - Boston University Alzheimer's Disease Center, Boston University School of 
      Medicine, Boston, MA 02118, USA.
FAU - Mez, Jesse
AU  - Mez J
AD  - Boston University Alzheimer's Disease Center, Boston University School of 
      Medicine, Boston, MA 02118, USA.
FAU - Alosco, Michael L
AU  - Alosco ML
AD  - Boston University Alzheimer's Disease Center, Boston University School of 
      Medicine, Boston, MA 02118, USA.
FAU - Cervantes-Arslanian, Anna
AU  - Cervantes-Arslanian A
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Stern, Robert
AU  - Stern R
AD  - Department of Anatomy & Neurobiology, Boston University School of Medicine, 
      Boston, MA 02118, USA.
FAU - Killiany, Ronald
AU  - Killiany R
AD  - Department of Anatomy & Neurobiology, Boston University School of Medicine, 
      Boston, MA 02118, USA.
LA  - eng
GR  - UL1 TR001430/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20200528
PL  - United States
TA  - Cereb Cortex Commun
JT  - Cerebral cortex communications
JID - 101767128
PMC - PMC7463163
OTO - NOTNLM
OT  - aging
OT  - brain connectomics
OT  - cognition
OT  - hippocampus
OT  - humans
OT  - magnetic resonance imaging
EDAT- 2020/09/10 06:00
MHDA- 2020/09/10 06:01
PMCR- 2020/05/28
CRDT- 2020/09/09 18:10
PHST- 2020/04/03 00:00 [received]
PHST- 2020/05/18 00:00 [revised]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/09/09 18:10 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/09/10 06:01 [medline]
PHST- 2020/05/28 00:00 [pmc-release]
AID - tgaa019 [pii]
AID - 10.1093/texcom/tgaa019 [doi]
PST - ppublish
SO  - Cereb Cortex Commun. 2020;1(1):tgaa019. doi: 10.1093/texcom/tgaa019. Epub 2020 
      May 28.