PMID- 32905289
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2048-8505 (Print)
IS  - 2048-8513 (Electronic)
IS  - 2048-8505 (Linking)
VI  - 13
IP  - 4
DP  - 2020 Aug
TI  - Association between urinary biomarkers and disease progression in adults with 
      autosomal dominant polycystic kidney disease.
PG  - 607-612
LID - 10.1093/ckj/sfz105 [doi]
AB  - BACKGROUND: Height-adjusted total kidney volume (htTKV) is considered as the best 
      predictor of kidney function in patients with autosomal dominant polycystic 
      kidney disease (ADPKD), but its limited predictive capacity stresses the need to 
      find new biomarkers of ADPKD progression. The aim of this study was to 
      investigate urinary biomarkers of ADPKD progression. METHODS: This observational 
      study included ADPKD patients, and two comparator groups of ischaemic and 
      non-ischaemic kidney injury: benign nephroangiosclerosis patients and 
      non-ischaemic chronic kidney disease (CKD) patients. Proteinuria, htTKV and 
      urinary levels of molecules are associated with ischaemia and/or tubular injury. 
      The slope of estimated glomerular filtration rate (eGFR) was used as a dependent 
      variable in univariate and multivariate models of kidney function decline. 
      RESULTS: The study included 130 patients with ADPKD, 55 with nephroangiosclerosis 
      and 40 with non-ischaemic CKD. All patients had increased urinary concentrations 
      of biomarkers associated with tubular lesions (liver fatty acid-binding protein, 
      kidney injury molecule-1, beta2-microglobulin) and molecules overexpressed under 
      ischaemic conditions [hypoxia-inducible factor-1alpha, vascular endothelial growth 
      factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1)]. These biomarkers 
      correlated positively with htTKV and negatively with the eGFR slope. htTKV was 
      the single best predictor of the eGFR slope variability in univariate analyses. 
      However, a multivariate model including urinary levels of beta2-microglobulin, MCP-1 
      and VEGF improved the capacity to predict the decline of eGFR in ADPKD patients 
      compared with htTKV alone. CONCLUSIONS: The urinary levels of molecules 
      associated with either renal ischaemia (VEGF and MCP-1) or tubular damage 
      (beta2-microglobulin) are associated with renal function deterioration in ADPKD 
      patients, and are, therefore, candidates as biomarkers of ADPKD progression.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.
FAU - Segarra-Medrano, Alfons
AU  - Segarra-Medrano A
AD  - Servicio de Nefrologia, Hospital Arnau de Vilanova, Lleida, Spain.
AD  - Institut de Recerca Biomedica, Lleida, Spain.
AD  - Vall d'Hebron Institut de Recerca, Barcelona, Spain.
FAU - Martin, Marisa
AU  - Martin M
AD  - Servicio de Nefrologia, Hospital Arnau de Vilanova, Lleida, Spain.
AD  - Institut de Recerca Biomedica, Lleida, Spain.
FAU - Agraz, Irene
AU  - Agraz I
AD  - Servicio de Nefrologia, Hospital Vall d'Hebron, Barcelona, Spain.
FAU - Vilaprinyo, Merce
AU  - Vilaprinyo M
AD  - Institut Catala de Nefrologia i Urologia, Barcelona, Spain.
FAU - Chamoun, Betty
AU  - Chamoun B
AD  - Servicio de Nefrologia, Hospital Vall d'Hebron, Barcelona, Spain.
FAU - Jatem, Elias
AU  - Jatem E
AD  - Servicio de Nefrologia, Hospital Arnau de Vilanova, Lleida, Spain.
AD  - Institut de Recerca Biomedica, Lleida, Spain.
FAU - Molina, Maria
AU  - Molina M
AD  - Servicio de Nefrologia, Hospital Arnau de Vilanova, Lleida, Spain.
AD  - Institut de Recerca Biomedica, Lleida, Spain.
FAU - Colas-Campas, Laura
AU  - Colas-Campas L
AD  - Institut de Recerca Biomedica, Lleida, Spain.
FAU - Garcia-Carrasco, Alicia
AU  - Garcia-Carrasco A
AD  - Institut de Recerca Biomedica, Lleida, Spain.
FAU - Roche, Sarai
AU  - Roche S
AD  - Servicio de Radiologia, Hospital Vall d'Hebron, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20190801
PL  - England
TA  - Clin Kidney J
JT  - Clinical kidney journal
JID - 101579321
PMC - PMC7467584
OTO - NOTNLM
OT  - autosomal dominant (ADPKD)
OT  - biomarkers
OT  - disease progression
OT  - glomerular filtration rate
OT  - polycystic kidney
OT  - total kidney volume
EDAT- 2020/09/10 06:00
MHDA- 2020/09/10 06:01
PMCR- 2019/08/01
CRDT- 2020/09/09 18:13
PHST- 2018/11/06 00:00 [received]
PHST- 2019/07/12 00:00 [accepted]
PHST- 2020/09/09 18:13 [entrez]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/09/10 06:01 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - sfz105 [pii]
AID - 10.1093/ckj/sfz105 [doi]
PST - epublish
SO  - Clin Kidney J. 2019 Aug 1;13(4):607-612. doi: 10.1093/ckj/sfz105. eCollection 
      2020 Aug.