PMID- 32905963
OWN - NLM
STAT- MEDLINE
DCOM- 20201218
LR  - 20201218
IS  - 1873-5711 (Electronic)
IS  - 1050-6411 (Linking)
VI  - 54
DP  - 2020 Oct
TI  - Post-activation depression of primary afferents reevaluated in humans.
PG  - 102460
LID - S1050-6411(20)30102-4 [pii]
LID - 10.1016/j.jelekin.2020.102460 [doi]
AB  - Amplitude variation of Hoffmann Reflex (H-reflex) was used as a tool to 
      investigate many neuronal networks. However, H-reflex itself is a subject to 
      intrinsic changes including post-activation depression (P-AD). We aimed to 
      investigate P-AD and its implication on motor control in humans. Upon tibial 
      nerve stimulation in 23 healthy participants, peak-to-peak amplitude change of 
      H-reflex was investigated using surface electromyography (SEMG) of soleus muscle. 
      Variety of stimulus intensities, interstimulus intervals (ISIs), voluntary 
      contraction levels/types and force recording were used to investigate the nature 
      of P-AD. We have shown that P-AD was significantly stronger in the shorter ISIs. 
      The only exception was the ISI of 200 msecs which had a weaker P-AD than some of 
      the longer ISIs. Sudden muscle relaxation, on the other hand, further increased 
      the effectiveness of the ongoing P-AD. Moreover, P-AD displayed its full effect 
      with the first stimulus when there was no muscle contraction and was efficient to 
      reduce the muscle force output by about 30%. These findings provide insight about 
      the variations and mechanism of P-AD and could lead to improvements in diagnostic 
      tools in neurological diseases.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Ozyurt, Mustafa Gorkem
AU  - Ozyurt MG
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey.
FAU - Topkara, Betilay
AU  - Topkara B
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey.
FAU - Senocak, Beatrice Selen
AU  - Senocak BS
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey.
FAU - Budan, Abdullah Salih
AU  - Budan AS
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey.
FAU - Yuce, Murat Necdet
AU  - Yuce MN
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey.
FAU - Turker, Kemal Sitki
AU  - Turker KS
AD  - Koc University, School of Medicine, 34450 Sariyer, Istanbul, Turkey. Electronic 
      address: kturker@ku.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20200829
PL  - England
TA  - J Electromyogr Kinesiol
JT  - Journal of electromyography and kinesiology : official journal of the 
      International Society of Electrophysiological Kinesiology
JID - 9109125
SB  - IM
MH  - Adult
MH  - *H-Reflex
MH  - Humans
MH  - Muscle Contraction
MH  - Muscle, Skeletal/physiology
MH  - *Neural Inhibition
MH  - Neurons, Afferent/*physiology
MH  - Tibial Nerve/physiology
OTO - NOTNLM
OT  - Electrical stimulation
OT  - Electromyogram
OT  - H-reflex
OT  - Motor control
OT  - Soleus muscle
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/09/10 06:00
MHDA- 2020/12/19 06:00
CRDT- 2020/09/09 20:13
PHST- 2020/05/16 00:00 [received]
PHST- 2020/08/05 00:00 [revised]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2020/12/19 06:00 [medline]
PHST- 2020/09/09 20:13 [entrez]
AID - S1050-6411(20)30102-4 [pii]
AID - 10.1016/j.jelekin.2020.102460 [doi]
PST - ppublish
SO  - J Electromyogr Kinesiol. 2020 Oct;54:102460. doi: 10.1016/j.jelekin.2020.102460. 
      Epub 2020 Aug 29.