PMID- 32906000
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 46
DP  - 2020 Nov
TI  - Coexistent MOG, NMDAR, CASPR2 antibody positivity: Triumph over the triumvirate.
PG  - 102468
LID - S2211-0348(20)30543-5 [pii]
LID - 10.1016/j.msard.2020.102468 [doi]
AB  - Myelin oligodendrocyte glycoprotein (MOG) antibody (MOG -Ab) positive cases can 
      have a focal encephalitis like presentation. Many reports of anti 
      N-methyl-D-aspartate receptor (NMDAR) encephalitis have documented simultaneous 
      coexistence of MOG-Ab which is explained by the coexpression of NMDA receptors 
      and MOG on oligodendrocytic processes. Contactin-associated protein-like 2 
      (CASPR2) is expressed in central and peripheral nervous system (PNS) axons and 
      there are no case reports of coexistent NMDAR, CASPR2 and MOG antibodies. We 
      describe a young adult male who had neuropsychiatric, cognitive symptoms and long 
      tract signs with a strong positivity for all three antibodies. Bilateral 
      cingulate gyri involvement, especially with contrast enhancement may be an 
      imaging clue suggesting coexistent MOG and NMDAR antibodies. Bilateral T2 
      hyperintensities affecting hippocampi, have been described in both CASPR2 and 
      anti NMDAR encephalitis. Our patient had both, bilateral cingulate and 
      hippocampal lesions, which may be an imaging clue favouring the presence of all 
      three antibodies.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Cherian, Ajith
AU  - Cherian A
AD  - Associate Professor, Department of Neurology, Sree Chitra Tirunal Institute for 
      Medical Sciences and Technology, Trivandrum , Kerala, PIN-695011, India.
FAU - Divya, K P
AU  - Divya KP
AD  - Assistant Professor, Department of Neurology, Sree Chitra Tirunal Institute for 
      Medical Sciences and Technology, Trivandrum, Kerala PIN-695011, India. Electronic 
      address: drdivyakp01@gmail.com.
FAU - Shetty, Sarath Chandra
AU  - Shetty SC
AD  - Senior Resident, Department of Neurology, Sree Chitra Tirunal Institute for 
      Medical Sciences and Technology, Trivandrum, Kerala PIN-695011, India.
FAU - Kannoth, Sudheeran
AU  - Kannoth S
AD  - Clinical Associate Professor, Neuroimmunology Laboratory, Department of 
      Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala PIN 682041, India. 
      Electronic address: sudheerank@aims.amrita.edu.
FAU - Thomas, Bejoy
AU  - Thomas B
AD  - Professor, Department of Imaging Sciences and Interventional Radiology, Sree 
      Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala 
      PIN-695011, India. Electronic address: bejoy@sctimst.ac.in.
LA  - eng
PT  - Letter
DEP - 20200825
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Autoantibodies)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnostic imaging
MH  - Autoantibodies
MH  - Humans
MH  - Male
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - *Receptors, N-Methyl-D-Aspartate
MH  - Young Adult
OTO - NOTNLM
OT  - Autoimmune encephalitis
OT  - Cingulate hyperintensity
OT  - Demyelination
OT  - Hippocampal hyperintensity
OT  - Immunofluorescence
EDAT- 2020/09/10 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/09 20:14
PHST- 2020/06/21 00:00 [received]
PHST- 2020/07/19 00:00 [revised]
PHST- 2020/08/23 00:00 [accepted]
PHST- 2020/09/10 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/09 20:14 [entrez]
AID - S2211-0348(20)30543-5 [pii]
AID - 10.1016/j.msard.2020.102468 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2020 Nov;46:102468. doi: 10.1016/j.msard.2020.102468. 
      Epub 2020 Aug 25.