PMID- 32906727
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 9
DP  - 2020 Sep 7
TI  - Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia.
LID - 10.3390/antiox9090836 [doi]
LID - 836
AB  - Cancer is a leading cause of the death worldwide. Since the National Cancer Act 
      in 1971, various cancer treatments were developed including chemotherapy, 
      surgery, radiation therapy and so forth. However, sequela of such cancer 
      therapies and cachexia are problem to the patients. The primary mechanism of 
      cancer sequela and cachexia is closely related to reactive oxygen species (ROS) 
      and inflammation. As antioxidant properties of numerous plant extracts have been 
      widely reported, plant-derived drugs may have efficacy on managing the sequela 
      and cachexia. In this study, recent seventy-four studies regarding plant extracts 
      showing ability to manage the sequela and cachexia were reviewed. Some 
      plant-derived antioxidants inhibited cancer proliferation and inflammation after 
      surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, 
      there are plant extracts that suppressed radiation-induced oxidative stress and 
      cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), 
      catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 
      (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by 
      inhibition of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), 
      interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant 
      extracts. This review focuses on the potential of plant extracts as great 
      therapeutic agents by controlling oxidative stress and inflammation.
FAU - Lee, Jinjoo
AU  - Lee J
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
FAU - Jeong, Myung In
AU  - Jeong MI
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
FAU - Kim, Hyo-Rim
AU  - Kim HR
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
FAU - Park, Hyejin
AU  - Park H
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
FAU - Moon, Won-Kyoung
AU  - Moon WK
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
FAU - Kim, Bonglee
AU  - Kim B
AUID- ORCID: 0000-0002-8678-156X
AD  - College of Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 
      05253, Korea.
AD  - Department of Pathology, College of Korean Medicine, Kyung Hee University, 
      Hoegi-dong Dongdaemun-gu, Seoul 05253, Korea.
AD  - Korean Medicine-Based Drug Repositioning Cancer Research Center, College of 
      Korean Medicine, Kyung Hee University, Hoegi-dong Dongdaemun-gu, Seoul 05253, 
      Korea.
LA  - eng
GR  - (No. 2020R1A5A201941311)/the National Research Foundation of Korea (NRF) grant 
      funded by the Korea government (MSIT)/
GR  - (NRF-2020R1I1A2066868)/Basic Science Research Program through the National 
      Research Foundation of Korea(NRF) funded by the Ministry of Education/
PT  - Journal Article
PT  - Review
DEP - 20200907
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7555300
OTO - NOTNLM
OT  - antioxidants
OT  - cachexia
OT  - cancer sequela
OT  - inflammation
OT  - oxidative stress
OT  - plant extracts
OT  - reactive oxygen species
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/11 06:00
MHDA- 2020/09/11 06:01
PMCR- 2020/09/07
CRDT- 2020/09/10 01:02
PHST- 2020/08/12 00:00 [received]
PHST- 2020/09/04 00:00 [revised]
PHST- 2020/09/04 00:00 [accepted]
PHST- 2020/09/10 01:02 [entrez]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2020/09/11 06:01 [medline]
PHST- 2020/09/07 00:00 [pmc-release]
AID - antiox9090836 [pii]
AID - antioxidants-09-00836 [pii]
AID - 10.3390/antiox9090836 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Sep 7;9(9):836. doi: 10.3390/antiox9090836.