PMID- 32907370
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20201214
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 40
IP  - 11
DP  - 2020 Nov
TI  - Increased ABCA1 (ATP-Binding Cassette Transporter A1)-Specific Cholesterol Efflux 
      Capacity in Schizophrenia.
PG  - 2728-2737
LID - 10.1161/ATVBAHA.120.314847 [doi]
AB  - OBJECTIVE: Patients with schizophrenia have increased long-term mortality 
      attributable to cardiovascular disease and commonly demonstrate features of mixed 
      dyslipidemia with low HDL-C (high-density lipoprotein cholesterol). The removal 
      of cholesterol from cells by HDL via specific ATP-binding cholesterol 
      transporters is a major functional property of HDL, and its measurement as 
      cholesterol efflux capacity (CEC) can predict cardiovascular risk. Whether HDL 
      function is impaired in patients with schizophrenia is unknown. Approach and 
      Results: We measured basal and ABCA1 (ATP-binding cassette transporter A1)- and 
      ABCG1 (ATP-binding cassette transporter G1)-dependent CEC, comparing patients 
      with schizophrenia with age- and sex-matched healthy controls, and related our 
      findings to nuclear magnetic resonance analysis of lipoprotein subclasses. Total 
      plasma cholesterol and LDL-C (low-density lipoprotein cholesterol) were 
      comparable between healthy controls (n=51) and patients (n=120), but patients 
      with schizophrenia had increased total plasma triglyceride, low HDL-C and apo 
      (apolipoprotein) A-I concentrations. Nuclear magnetic resonance analysis 
      indicated a marked (15-fold) increase in large triglyceride-rich lipoprotein 
      particle concentration, increased small dense LDL particles, and fewer large HDL 
      particles. Despite lower HDL-C concentration, basal CEC was 13.7+/-1.6% higher, 
      ABCA1-specific efflux was 35.9+/-1.6% higher, and ABCG1 efflux not different, in 
      patients versus controls. In patients with schizophrenia, ABCA1-specific efflux 
      correlated with the abundance of small 7.8 nm HDL particles but not with serum 
      plasminogen or triglyceride levels. CONCLUSIONS: Patients with schizophrenia have 
      increased concentrations of atherogenic apoB-containing lipoproteins, decreased 
      concentrations of large HDL particles, but enhanced ABCA1-mediated CEC. In this 
      population, preventative strategies should focus on reducing atherogenic 
      lipoproteins rather than increasing CEC.
FAU - Luquain-Costaz, Celine
AU  - Luquain-Costaz C
AD  - INSERM U1060, Carmen laboratory, INSA de Lyon, Villeurbanne, France (C.L.-C.).
FAU - Kockx, Maaike
AU  - Kockx M
AD  - ANZAC Research institute, Concord Repatriation General Hospital and University of 
      Sydney, Australia (M.K., M.A., V.C., W.J., L.K.).
FAU - Anastasius, Malcolm
AU  - Anastasius M
AD  - ANZAC Research institute, Concord Repatriation General Hospital and University of 
      Sydney, Australia (M.K., M.A., V.C., W.J., L.K.).
FAU - Chow, Vincent
AU  - Chow V
AD  - ANZAC Research institute, Concord Repatriation General Hospital and University of 
      Sydney, Australia (M.K., M.A., V.C., W.J., L.K.).
AD  - Department of Cardiology, Concord Repatriation General Hospital, Sydney, 
      Australia (V.C., L.K.).
FAU - Kontush, Anatol
AU  - Kontush A
AD  - INSERM Unit 1166, Faculty of Medicine Pitie-Salpetriere and Sorbonne University, 
      Paris, France (A.K.).
FAU - Jessup, Wendy
AU  - Jessup W
AD  - ANZAC Research institute, Concord Repatriation General Hospital and University of 
      Sydney, Australia (M.K., M.A., V.C., W.J., L.K.).
FAU - Kritharides, Leonard
AU  - Kritharides L
AD  - ANZAC Research institute, Concord Repatriation General Hospital and University of 
      Sydney, Australia (M.K., M.A., V.C., W.J., L.K.).
AD  - Department of Cardiology, Concord Repatriation General Hospital, Sydney, 
      Australia (V.C., L.K.).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200910
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/genetics/*metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/genetics/metabolism
MH  - Adult
MH  - Animals
MH  - Antipsychotic Agents/therapeutic use
MH  - Biomarkers/blood
MH  - CHO Cells
MH  - Case-Control Studies
MH  - Cholesterol/*blood
MH  - Cricetulus
MH  - Dyslipidemias/*blood/diagnosis
MH  - Female
MH  - Humans
MH  - Lipoproteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*blood/diagnosis/drug therapy
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - ABCA1
OT  - cholesterol
OT  - cholesterol efflux
OT  - high density lipoprotein
OT  - lipoprotein
OT  - schizophrenia
OT  - triglyceride
EDAT- 2020/09/11 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/09/10 05:24
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/09/10 05:24 [entrez]
AID - 10.1161/ATVBAHA.120.314847 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2728-2737. doi: 
      10.1161/ATVBAHA.120.314847. Epub 2020 Sep 10.