PMID- 32908299
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20240322
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 21
IP  - 2
DP  - 2021 Feb
TI  - Genetic models of human and mouse dendritic cell development and function.
PG  - 101-115
LID - 10.1038/s41577-020-00413-x [doi]
AB  - Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors 
      that have numerous shared characteristics between mice and humans. Human 
      counterparts of mouse DC progenitors have been identified by their shared 
      transcriptional signatures and developmental potential. New findings continue to 
      revise models of DC ontogeny but it is well accepted that DCs can be divided into 
      two main functional groups. Classical DCs include type 1 and type 2 subsets, 
      which can detect different pathogens, produce specific cytokines and present 
      antigens to polarize mainly naive CD8(+) or CD4(+) T cells, respectively. By 
      contrast, the function of plasmacytoid DCs is largely innate and restricted to 
      the detection of viral infections and the production of type I interferon. Here, 
      we discuss genetic models of mouse DC development and function that have aided in 
      correlating ontogeny with function, as well as how these findings can be 
      translated to human DCs and their progenitors.
FAU - Anderson, David A 3rd
AU  - Anderson DA 3rd
AD  - Department of Pathology and Immunology, School of Medicine, Washington University 
      in St. Louis, St. Louis, MO, USA.
FAU - Dutertre, Charles-Antoine
AU  - Dutertre CA
AD  - Singapore Immunology Network, Agency for Science, Technology and Research, 
      Singapore, Singapore.
FAU - Ginhoux, Florent
AU  - Ginhoux F
AUID- ORCID: 0000-0002-2857-7755
AD  - Singapore Immunology Network, Agency for Science, Technology and Research, 
      Singapore, Singapore.
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
AD  - Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, 
      Singapore, Singapore.
FAU - Murphy, Kenneth M
AU  - Murphy KM
AD  - Department of Pathology and Immunology, School of Medicine, Washington University 
      in St. Louis, St. Louis, MO, USA. kmurphy@wustl.edu.
AD  - Howard Hughes Medical Institute, School of Medicine, Washington University in St. 
      Louis, St. Louis, MO, USA. kmurphy@wustl.edu.
LA  - eng
GR  - R01 AI150297/AI/NIAID NIH HHS/United States
GR  - R01 AI162643/AI/NIAID NIH HHS/United States
GR  - R01 CA248919/CA/NCI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200909
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*genetics
MH  - Cell Lineage
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Mice
MH  - *Models, Genetic
MH  - Monocytes/physiology
PMC - PMC10955724
MID - NIHMS1970082
COIS- Competing interests The authors declare no competing interests.
EDAT- 2020/09/11 06:00
MHDA- 2021/02/23 06:00
PMCR- 2024/03/21
CRDT- 2020/09/10 05:34
PHST- 2020/07/28 00:00 [accepted]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/09/10 05:34 [entrez]
PHST- 2024/03/21 00:00 [pmc-release]
AID - 10.1038/s41577-020-00413-x [pii]
AID - 10.1038/s41577-020-00413-x [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2021 Feb;21(2):101-115. doi: 10.1038/s41577-020-00413-x. Epub 
      2020 Sep 9.