PMID- 32908538
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1687-9627 (Print)
IS  - 1687-9635 (Electronic)
VI  - 2020
DP  - 2020
TI  - Eosinophilic Gastroenteritis with a Relapsing and Remitting Course with Presence 
      of Autoimmune Antibodies.
PG  - 1745834
LID - 10.1155/2020/1745834 [doi]
LID - 1745834
AB  - BACKGROUND: Eosinophilic gastroenteritis (EGE) is an uncommon disease 
      characterized by eosinophilic infiltration of the digestive tract, which occurs 
      due to an uncertain aetiology. Although autoimmune diseases can later present as 
      EGE, it is unusual for EGE to have positive autoimmune antibodies without the 
      presence of an overt autoimmune disease. Case presentation. We report a 
      38-year-old previously healthy man who presented with abdominal discomfort and 
      loose stools with pleural and peritoneal effusions progressing over several 
      weeks. His investigations revealed severe eosinophilia in peripheral blood and 
      ascitic fluid, and a laparoscopic full-thickness biopsy from the ileum 
      demonstrated infiltration of eosinophils in all three layers of the intestine. 
      There were no clinical features or investigations suggestive of parasitic 
      disease, other diseases associated with eosinophilia, or autoimmune disease. 
      Further investigations showed a highly positive ANA, positive p-ANCA, but did not 
      meet the criteria to diagnose a specific autoimmune disease. The eosinophilia 
      responded to an elimination diet with gradual resolution of eosinophilia and 
      effusions, and once it reappeared after introduction of a normal diet. 
      CONCLUSION: EGE presenting as peripheral blood and ascitic fluid eosinophilia 
      with the presence of pleural and/or peritoneal effusions is uncommon. 
      Eosinophilic gastroenteritis can be associated with autoantibody positivity 
      without any evidence of overt autoimmune disease manifestations. Elimination diet 
      can be used as a potential option to prevent recurrences of EGE.
CI  - Copyright (c) 2020 Chathuranga Lakmal Fonseka et al.
FAU - Fonseka, Chathuranga Lakmal
AU  - Fonseka CL
AUID- ORCID: 0000-0003-3364-6257
AD  - University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka.
AD  - Faculty of Medicine, University of Ruhuna, Matara, Sri Lanka.
FAU - Nanayakkara, Sunali
AU  - Nanayakkara S
AD  - University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka.
FAU - Singhapura, S D A L
AU  - Singhapura SDAL
AD  - University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka.
FAU - Herath, H M M
AU  - Herath HMM
AD  - Faculty of Medicine, University of Ruhuna, Matara, Sri Lanka.
FAU - Bodinayake, C K
AU  - Bodinayake CK
AD  - Faculty of Medicine, University of Ruhuna, Matara, Sri Lanka.
LA  - eng
PT  - Case Reports
DEP - 20200818
PL  - United States
TA  - Case Rep Med
JT  - Case reports in medicine
JID - 101512910
PMC - PMC7450306
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/09/11 06:00
MHDA- 2020/09/11 06:01
PMCR- 2020/08/18
CRDT- 2020/09/10 05:35
PHST- 2020/07/03 00:00 [received]
PHST- 2020/08/02 00:00 [revised]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/09/10 05:35 [entrez]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2020/09/11 06:01 [medline]
PHST- 2020/08/18 00:00 [pmc-release]
AID - 10.1155/2020/1745834 [doi]
PST - epublish
SO  - Case Rep Med. 2020 Aug 18;2020:1745834. doi: 10.1155/2020/1745834. eCollection 
      2020.