PMID- 32908640
OWN - NLM
STAT- MEDLINE
DCOM- 20210512
LR  - 20240329
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2020
DP  - 2020
TI  - Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not 
      Associated with Xanthine Oxidase Activity.
PG  - 8209727
LID - 10.1155/2020/8209727 [doi]
LID - 8209727
AB  - Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial 
      nephropathy which is followed by the progression of kidney fibrosis to end-stage 
      kidney failure. The critical involvement of poisons in food (aristolochic acid 
      (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive 
      factors which contribute to the pathogenesis of BEN, due to reactive oxygen 
      species (ROS) liberation and/or decreased antioxidative defence system. The aim 
      of the study is to distinguish a possible systemic and local origin of ROS 
      through the measurement of xanthine oxidase (XO) activity in urine and plasma, 
      along with the determination of the oxidative changes in lipids and proteins. The 
      study included 50 patients with BEN and 38 control healthy subjects. We noted 
      increased levels of both thiobarbituric acid-reactive substances (TBARS) and 
      advanced oxidation protein products (AOPPs) in the plasma of patients with BEN, 
      compared to the control group (p < 0.001). The urinary levels of AOPPs were 
      higher in patients with BEN in comparison to the control (p < 0.001). The 
      specific activity of XO was significantly lower in plasma and urine in BEN 
      samples, compared to controls (p < 0.005). Based on these results, we hypothesize 
      that XO might not be considered a direct systemic or local contributor to ROS 
      production in BEN, most probably because of the diminished kidney functional 
      tissue mass and/or AA-induced changes in purine nucleotide conformation. The 
      increased AOPP and TBARS level in both plasma and urine in BEN may predict ROS 
      systemic liberation with toxic local effects.
CI  - Copyright (c) 2020 Andrej Veljkovic et al.
FAU - Veljkovic, Andrej
AU  - Veljkovic A
AUID- ORCID: 0000-0001-5950-7517
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
FAU - Hadzi-Dokic, Jovan
AU  - Hadzi-Dokic J
AD  - Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia.
FAU - Sokolovic, Dusan
AU  - Sokolovic D
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
FAU - Cukuranovic, Rade
AU  - Cukuranovic R
AD  - Clinical Center in Nis, 18000 Nis, Serbia.
FAU - Cukuranovic-Kokoris, Jovana
AU  - Cukuranovic-Kokoris J
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
FAU - Basic, Dragoslav
AU  - Basic D
AD  - Clinical Center in Nis, 18000 Nis, Serbia.
FAU - Dordevic, Branka
AU  - Dordevic B
AUID- ORCID: 0000-0002-4521-1253
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
FAU - Stojanovic, Marko
AU  - Stojanovic M
AD  - Clinical Center in Nis, 18000 Nis, Serbia.
FAU - Smelcerovic, Andrija
AU  - Smelcerovic A
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
FAU - Kocic, Gordana
AU  - Kocic G
AD  - Faculty of Medicine, University of Nis, 18000 Nis, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20200818
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Balkan Nephropathy/*enzymology/*pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Xanthine Oxidase/*metabolism
PMC - PMC7450339
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2020/09/11 06:00
MHDA- 2021/05/13 06:00
PMCR- 2020/08/18
CRDT- 2020/09/10 05:35
PHST- 2020/05/19 00:00 [received]
PHST- 2020/07/09 00:00 [revised]
PHST- 2020/07/25 00:00 [accepted]
PHST- 2020/09/10 05:35 [entrez]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2021/05/13 06:00 [medline]
PHST- 2020/08/18 00:00 [pmc-release]
AID - 10.1155/2020/8209727 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2020 Aug 18;2020:8209727. doi: 10.1155/2020/8209727. 
      eCollection 2020.