PMID- 32909606
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 47
IP  - 2
DP  - 2021 Mar 16
TI  - The Latent Structure of Negative Symptoms in Individuals With Attenuated 
      Psychosis Syndrome and Early Psychosis: Support for the 5 Consensus Domains.
PG  - 386-394
LID - 10.1093/schbul/sbaa129 [doi]
AB  - Negative symptoms are prevalent in the prodromal and first-episode phases of 
      psychosis and highly predictive of poor clinical outcomes (eg, liability for 
      conversion and functioning). However, the latent structure of negative symptoms 
      is unclear in the early phases of illness. Determining the latent structure of 
      negative symptoms in early psychosis (EP) is of critical importance for early 
      identification, prevention, and treatment efforts. In the current study, 
      confirmatory factor analysis was used to evaluate latent structure in relation to 
      4 theoretically derived models: 1. a 1-factor model, 2. a 2-factor model with 
      expression (EXP) and motivation and pleasure (MAP) factors, 3. a 5-factor model 
      with separate factors for the 5 National Institute of Mental Health (NIMH) 
      consensus development conference domains (blunted affect, alogia, anhedonia, 
      avolition, and asociality), and 4. a hierarchical model with 2 second-order 
      factors reflecting EXP and MAP, as well as 5 first-order factors reflecting the 5 
      consensus domains. Participants included 164 individuals at clinical high risk 
      (CHR) who met the criteria for a prodromal syndrome and 377 EP patients who were 
      rated on the Brief Negative Symptom Scale. Results indicated that the 1- and 
      2-factor models provided poor fit for the data. The 5-factor and hierarchical 
      models provided excellent fit, with the 5-factor model outperforming the 
      hierarchical model. These findings suggest that similar to the chronic phase of 
      schizophrenia, the latent structure of negative symptom is best conceptualized in 
      relation to the 5 consensus domains in the CHR and EP populations. Implications 
      for early identification, prevention, and treatment are discussed.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center. All rights reserved. For permissions, 
      please email: journals.permissions@oup.com.
FAU - Chang, Wing Chung
AU  - Chang WC
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
AD  - State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, 
      Pok Fu Lam, Hong Kong.
FAU - Strauss, Gregory P
AU  - Strauss GP
AD  - Department of Psychology, University of Georgia, Athens, GA.
FAU - Ahmed, Anthony O
AU  - Ahmed AO
AD  - Department of Psychiatry, Weill Cornell Medicine, New York, NY.
FAU - Wong, Sandra C Y
AU  - Wong SCY
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
FAU - Chan, Joe K N
AU  - Chan JKN
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
FAU - Lee, Edwin H M
AU  - Lee EHM
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
FAU - Chan, Sherry K W
AU  - Chan SKW
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
AD  - State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, 
      Pok Fu Lam, Hong Kong.
FAU - Hui, Christy L M
AU  - Hui CLM
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
FAU - James, Sydney H
AU  - James SH
AD  - Department of Psychology, University of Georgia, Athens, GA.
FAU - Chapman, Hannah C
AU  - Chapman HC
AD  - Department of Psychology, University of Georgia, Athens, GA.
FAU - Chen, Eric Y H
AU  - Chen EYH
AD  - Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
AD  - State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, 
      Pok Fu Lam, Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affective Symptoms/etiology/*physiopathology
MH  - Anhedonia/*physiology
MH  - Aphasia/etiology/*physiopathology
MH  - Consensus
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Statistical
MH  - Motivation/*physiology
MH  - Neuropsychological Tests
MH  - Psychometrics/*statistics & numerical data
MH  - Psychotic Disorders/complications/*physiopathology
MH  - *Social Behavior
MH  - Syndrome
MH  - Young Adult
PMC - PMC7965067
OTO - NOTNLM
OT  - alogia
OT  - anhedonia
OT  - asociality
OT  - avolition
OT  - blunted affect
EDAT- 2020/09/11 06:00
MHDA- 2021/11/23 06:00
PMCR- 2021/09/10
CRDT- 2020/09/10 08:43
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2020/09/10 08:43 [entrez]
PHST- 2021/09/10 00:00 [pmc-release]
AID - 5903607 [pii]
AID - sbaa129 [pii]
AID - 10.1093/schbul/sbaa129 [doi]
PST - ppublish
SO  - Schizophr Bull. 2021 Mar 16;47(2):386-394. doi: 10.1093/schbul/sbaa129.