PMID- 32910393
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 169
IP  - 4
DP  - 2020 Aug
TI  - Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic 
      Zone of the Brain in SHR Rats.
PG  - 576-581
LID - 10.1007/s10517-020-04932-4 [doi]
AB  - We studied spatial organization and structural characteristics of striatal glial 
      cells in spontaneously hypertensive rats (SHR) in 48 h after 30-min focal 
      ischemia. Immunocytochemical analysis of nestin and glial fibrillar acidic 
      protein (GFAP) revealed 3 types of activated astrocytes: expressing only nestin, 
      only GFAP, or both markers. There were no nestin-immunopositive astrocytes in the 
      striatum of sham-operated rats. In cells expressing nestin and GFAP, localization 
      of these markers did not completely coincide, which can be explained by different 
      functions of these proteins or formation of heterodimers of nestin with other 
      intermediate filament proteins.
FAU - Tsyba, D L
AU  - Tsyba DL
AD  - Department of General and Local Morphology, Laboratory of Functional Morphology 
      of Central and Peripheral Nervous System, Institute of Experimental Medicine, St. 
      Petersburg, Russia. dariasnow97@gmail.com.
FAU - Kirik, O V
AU  - Kirik OV
AD  - Department of General and Local Morphology, Laboratory of Functional Morphology 
      of Central and Peripheral Nervous System, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
FAU - Kolpakova, M E
AU  - Kolpakova ME
AD  - Department if Pathophysiology, I. P. Pavlov First St. Petersburg State Medical 
      University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
FAU - Yakovleva, A A
AU  - Yakovleva AA
AD  - Department if Pathophysiology, I. P. Pavlov First St. Petersburg State Medical 
      University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
FAU - Korzhevskii, D E
AU  - Korzhevskii DE
AD  - Department of General and Local Morphology, Laboratory of Functional Morphology 
      of Central and Peripheral Nervous System, Institute of Experimental Medicine, St. 
      Petersburg, Russia.
LA  - eng
PT  - Journal Article
DEP - 20200910
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (GFAP protein, rat)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nes protein, rat)
RN  - 0 (Nestin)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism/pathology
MH  - Brain Ischemia/*genetics/metabolism/pathology
MH  - Corpus Striatum/*metabolism/pathology
MH  - Gene Expression
MH  - Glial Fibrillary Acidic Protein/*genetics/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Nestin/*genetics/metabolism
MH  - Neurogenesis/genetics
MH  - Neuroglia/*metabolism/pathology
MH  - Rats
MH  - Rats, Inbred SHR
OTO - NOTNLM
OT  - focal cerebral ischemia
OT  - glial fibrillary acidic protein
OT  - nestin
OT  - neural progenitor cells
EDAT- 2020/09/11 06:00
MHDA- 2021/07/10 06:00
CRDT- 2020/09/10 12:27
PHST- 2019/12/17 00:00 [received]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/09/10 12:27 [entrez]
AID - 10.1007/s10517-020-04932-4 [pii]
AID - 10.1007/s10517-020-04932-4 [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2020 Aug;169(4):576-581. doi: 10.1007/s10517-020-04932-4. Epub 
      2020 Sep 10.