PMID- 32911225
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 112
DP  - 2020 Dec
TI  - Effects of design, porosity and biodegradation on mechanical and morphological 
      properties of additive-manufactured triply periodic minimal surface scaffolds.
PG  - 104064
LID - S1751-6161(20)30613-5 [pii]
LID - 10.1016/j.jmbbm.2020.104064 [doi]
AB  - The main aim of this paper is to assess the impacts of design, porosity, and 
      biodegradation on the mechanical and morphological properties of triply periodic 
      minimal surface (TPMS) scaffolds. The TPMS scaffolds were designed and 
      manufactured with different porosities by using fused deposing modeling (FDM) 
      technique. The biodegradation test on the scaffolds was performed for four and 
      six months. The mechanical properties were assessed employing ASTM standard 
      compression test and an in-situ mechanical testing stage. Microcomputed 
      tomography (Micro-CT) technique was used to investigate detailed morphological 
      properties of the scaffolds in 3D. Results indicate that the Schwarz-D scaffolds 
      exhibit the highest compressive strength in lower porosity scaffolds but lose 
      mechanical properties when the porosity was increased. On the contrary, Gyroid 
      scaffolds maintain their strength as the porosity was increased. In addition, 
      Gyroid scaffolds preserve a higher percentage of their compressive strength after 
      six months of biodegradation. It was also observed that biodegradation phenomenon 
      transformed the mechanical failure mode of the scaffolds from ductile to brittle. 
      Morphological analysis of the scaffolds revealed detailed information, which 
      support and clarify the observed variations in the mechanical properties.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Karimipour-Fard, Pedram
AU  - Karimipour-Fard P
AD  - Faculty of Engineering and Applied Science, University of Ontario Institute of 
      Technology, Ontario, Canada. Electronic address: pedram.karimipourfard@uoit.ca.
FAU - Behravesh, Amir H
AU  - Behravesh AH
AD  - Faculty of Engineering and Applied Science, University of Ontario Institute of 
      Technology, Ontario, Canada.
FAU - Jones-Taggart, Holly
AU  - Jones-Taggart H
AD  - Faculty of Health Sciences, University of Ontario Institute of Technology, 
      Ontario, Canada.
FAU - Pop-Iliev, Remon
AU  - Pop-Iliev R
AD  - Faculty of Engineering and Applied Science, University of Ontario Institute of 
      Technology, Ontario, Canada.
FAU - Rizvi, Ghaus
AU  - Rizvi G
AD  - Faculty of Engineering and Applied Science, University of Ontario Institute of 
      Technology, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200831
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
SB  - IM
MH  - *Bone and Bones
MH  - Compressive Strength
MH  - Porosity
MH  - Surface Properties
MH  - Tissue Engineering
MH  - *Tissue Scaffolds
MH  - X-Ray Microtomography
OTO - NOTNLM
OT  - Additive manufacturing
OT  - Biodegradation
OT  - Mechanical properties
OT  - Microcomputed tomography
OT  - Polymeric scaffold
OT  - Triply periodic minimal surfaces (TPMS)
EDAT- 2020/09/11 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/09/10 20:14
PHST- 2020/07/03 00:00 [received]
PHST- 2020/08/06 00:00 [revised]
PHST- 2020/08/22 00:00 [accepted]
PHST- 2020/09/11 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/09/10 20:14 [entrez]
AID - S1751-6161(20)30613-5 [pii]
AID - 10.1016/j.jmbbm.2020.104064 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2020 Dec;112:104064. doi: 10.1016/j.jmbbm.2020.104064. 
      Epub 2020 Aug 31.