PMID- 32912249
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 15
IP  - 1
DP  - 2020 Sep 10
TI  - Clinical study on primary screening of oral cancer and precancerous lesions by 
      oral cytology.
PG  - 107
LID - 10.1186/s13000-020-01027-6 [doi]
LID - 107
AB  - BACKGROUND: This study was conducted to compare the histological diagnostic 
      accuracy of conventional oral-based cytology and liquid-based cytology (LBC) 
      methods. METHODS: Histological diagnoses of 251 cases were classified as negative 
      (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive 
      [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. 
      Cytological diagnoses were classified as negative for intraepithelial lesion or 
      malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral 
      high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological 
      diagnostic results were compared with histology results. RESULTS: Of NILM 
      cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), 
      conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was 
      negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL 
      cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC 
      n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC 
      n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the 
      most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the 
      diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, 
      the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, 
      specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and 
      false-negative rate of 20.6%/23.3%. CONCLUSIONS: LBC method was superior to 
      conventional cytodiagnosis methods. It was especially superior for OLSIL and 
      OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is 
      necessary to make a comprehensive diagnosis considering the clinical findings.
FAU - Sukegawa, Shintaro
AU  - Sukegawa S
AUID- ORCID: 0000-0001-7986-2735
AD  - Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central 
      Hospital, 1-2-1, Asahi-machi, Takamatsu, Kagawa, 760-8557, Japan. 
      gouwan19@gmail.com.
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. 
      gouwan19@gmail.com.
FAU - Ono, Sawako
AU  - Ono S
AD  - Department of Pathology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, 
      Japan.
AD  - Department of Pathology, Okayama University Graduate School of Medicine, 
      Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
FAU - Nakano, Keisuke
AU  - Nakano K
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Takabatake, Kiyofumi
AU  - Takabatake K
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Kawai, Hotaka
AU  - Kawai H
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Nagatsuka, Hitoshi
AU  - Nagatsuka H
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Furuki, Yoshihiko
AU  - Furuki Y
AD  - Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central 
      Hospital, 1-2-1, Asahi-machi, Takamatsu, Kagawa, 760-8557, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200910
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
SB  - IM
MH  - Carcinoma in Situ/*diagnosis
MH  - Cross-Sectional Studies
MH  - Cytodiagnosis/*methods
MH  - Early Detection of Cancer/methods
MH  - Humans
MH  - Mouth Neoplasms/*diagnosis
MH  - Precancerous Conditions/*diagnosis
MH  - Squamous Cell Carcinoma of Head and Neck/*diagnosis
PMC - PMC7488236
OTO - NOTNLM
OT  - Cytology
OT  - Inflammation
OT  - Liquid-based cytology
OT  - Pathology
OT  - Screening
COIS- The authors declare that they have no competing interests.
EDAT- 2020/09/12 06:00
MHDA- 2021/07/10 06:00
PMCR- 2020/09/10
CRDT- 2020/09/11 05:31
PHST- 2020/06/15 00:00 [received]
PHST- 2020/09/04 00:00 [accepted]
PHST- 2020/09/11 05:31 [entrez]
PHST- 2020/09/12 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/09/10 00:00 [pmc-release]
AID - 10.1186/s13000-020-01027-6 [pii]
AID - 1027 [pii]
AID - 10.1186/s13000-020-01027-6 [doi]
PST - epublish
SO  - Diagn Pathol. 2020 Sep 10;15(1):107. doi: 10.1186/s13000-020-01027-6.