PMID- 32912740
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 1476-5411 (Electronic)
IS  - 1367-0484 (Linking)
VI  - 44
IP  - 1
DP  - 2021 Feb
TI  - The safety of orthokeratology in myopic children and analysis of related factors.
PG  - 89-93
LID - S1367-0484(20)30166-1 [pii]
LID - 10.1016/j.clae.2020.08.011 [doi]
AB  - OBJECTIVE: To evaluate the safety of overnight orthokeratology (OK) wear and 
      explore whether factors such as age, refraction and allergic conjunctivitis (AC) 
      history were associated with corneal adverse events (AEs) incidence. METHODS: 
      Medical records of consecutive patients who started OK for myopia correction and 
      continued for more than one year were retrospectively reviewed. Clinical data 
      including sex, baseline age, spherical equivalent refraction (SER), and related 
      medical histories were retrieved. A total of 489 eyes from 260 patients (age: 
      8-15 years; SER: -1.00 to -6.00 D) were included. Corneal adverse events were the 
      primary outcome. The generalized estimating equations model was used to evaluate 
      the effects of sex, age, SER, and allergic conjunctivitis history on corneal AE 
      incidence over the one-year period. RESULTS: A total of 111 eyes (22.7%) had 
      corneal AE during the one-year follow-up (corneal staining [n = 106], corneal 
      infiltration [n = 5]) and the incidence of significant AE was 6.9%. The corneal 
      AE incidence was associated with age (OR = 0.874, 95%CI = 0.781-0.978, p = 
      0.019); SER (OR=0.632, 95%CI=0.531-0.754, p < 0.001); and AC (OR=1.706, 
      95%CI=1.017-2.860, p = 0.043). High refraction was the key risk factor for 
      significant AE (OR=0.542, 95%CI=0.401-0.732, p < 0.001). CONCLUSIONS: 
      Orthokeratology is a safe option for children with myopia. Younger age, higher 
      myopia, and AC were risk factors for corneal AE in OK wearers. Whereas, only 
      higher myopia was a risk factor for significant AE.
CI  - Copyright (c) 2020 British Contact Lens Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Hu, Peike
AU  - Hu P
AD  - The Second Affiliated Hospital, Zhejiang University School of Medicine, Eye 
      Center, Hangzhou, Zhejiang, China.
FAU - Zhao, Yingying
AU  - Zhao Y
AD  - The Second Affiliated Hospital, Zhejiang University School of Medicine, Eye 
      Center, Hangzhou, Zhejiang, China.
FAU - Chen, Duya
AU  - Chen D
AD  - The Second Affiliated Hospital, Zhejiang University School of Medicine, Eye 
      Center, Hangzhou, Zhejiang, China.
FAU - Ni, Hailong
AU  - Ni H
AD  - The Second Affiliated Hospital, Zhejiang University School of Medicine, Eye 
      Center, Hangzhou, Zhejiang, China. Electronic address: 2101092@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200908
PL  - England
TA  - Cont Lens Anterior Eye
JT  - Contact lens & anterior eye : the journal of the British Contact Lens Association
JID - 9712714
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cornea
MH  - Corneal Topography
MH  - Humans
MH  - *Myopia/epidemiology/therapy
MH  - *Orthokeratologic Procedures/adverse effects
MH  - Refraction, Ocular
MH  - Retrospective Studies
OTO - NOTNLM
OT  - adverse event
OT  - allergic conjunctivitis
OT  - myopia
OT  - orthokeratology
EDAT- 2020/09/12 06:00
MHDA- 2021/09/01 06:00
CRDT- 2020/09/11 05:37
PHST- 2020/05/20 00:00 [received]
PHST- 2020/08/27 00:00 [revised]
PHST- 2020/08/29 00:00 [accepted]
PHST- 2020/09/12 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2020/09/11 05:37 [entrez]
AID - S1367-0484(20)30166-1 [pii]
AID - 10.1016/j.clae.2020.08.011 [doi]
PST - ppublish
SO  - Cont Lens Anterior Eye. 2021 Feb;44(1):89-93. doi: 10.1016/j.clae.2020.08.011. 
      Epub 2020 Sep 8.