PMID- 32913554
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 12
IP  - 8
DP  - 2020
TI  - Targeting hepcidin improves cognitive impairment and reduces iron deposition in a 
      diabetic rat model.
PG  - 4830-4839
AB  - Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM) 
      that may be related to iron deposition in the brain. Hepcidin is expressed in the 
      brain and has the ability to regulate iron. Therefore, this study explored the 
      role of hepcidin in hippocampal iron deposition and cognitive impairment in T2DM. 
      The effects of a recombinant adeno-associated virus targeting hepcidin 
      (AAV-hepcidin) for hippocampal iron content and cognitive function were 
      investigated in a T2DM rat model induced by streptozotocin and a high-fat diet. 
      Adult male rats (n = 32) were categorized as either C-saline (normal control), 
      M-saline (T2DM), M-blank (AAV-blank + T2DM), or M-hepcidin (AAV-hepcidin + T2DM). 
      Hippocampal iron content was assessed using quantitative susceptibility mapping. 
      Morris water maze (MWM) testing was used to assess the cognitive function. 
      Magnetic resonance imaging indicated that hippocampal susceptibility values were 
      significantly increased bilaterally in T2DM rats compared with controls (P = 
      0.044, P = 0.043). Compared with the M-blank group, the M-hepcidin group 
      exhibited significantly decreased hippocampal susceptibility values bilaterally 
      (P = 0.007, P = 0.030). Compared with the M-saline group, susceptibility values 
      from left hippocampus in the M-hepcidin group were significantly reduced (P = 
      0.002). MWM results showed that the performance of T2DM rats was significantly 
      decreased from that of control rats. Compared with the M-saline and M-blank 
      groups, the performance of the M-hepcidin group was significantly increased. 
      These studies demonstrate that T2DM rats developed cognitive impairment and iron 
      deposits in the hippocampus, both of which were improved by AAV-hepcidin 
      administration.
CI  - AJTR Copyright (c) 2020.
FAU - Liu, Juan
AU  - Liu J
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University Chongqing 400715, PR China.
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Hu, Xiaofei
AU  - Hu X
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Xue, Yuan
AU  - Xue Y
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Liu, Chen
AU  - Liu C
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Liu, Daihong
AU  - Liu D
AD  - Department of Medical Imaging, Chongqing University Cancer Hospital Chongqing 
      400030, PR China.
FAU - Shang, Yongning
AU  - Shang Y
AD  - Department of Ultrasound, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Shi, Yanshu
AU  - Shi Y
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Cheng, Lin
AU  - Cheng L
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
FAU - Zhang, Jiqiang
AU  - Zhang J
AD  - Department of Neurobiology, Army Medical University Chongqing 400038, PR China.
FAU - Chen, Antao
AU  - Chen A
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University Chongqing 400715, PR China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University) Chongqing 400038, PR China.
LA  - eng
PT  - Journal Article
DEP - 20200815
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC7476126
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - cognitive impairment
OT  - hepcidin
OT  - iron deposition
OT  - magnetic resonance imaging
OT  - quantitative susceptibility mapping
COIS- None.
EDAT- 2020/09/12 06:00
MHDA- 2020/09/12 06:01
PMCR- 2020/08/15
CRDT- 2020/09/11 05:44
PHST- 2020/02/22 00:00 [received]
PHST- 2020/07/05 00:00 [accepted]
PHST- 2020/09/11 05:44 [entrez]
PHST- 2020/09/12 06:00 [pubmed]
PHST- 2020/09/12 06:01 [medline]
PHST- 2020/08/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2020 Aug 15;12(8):4830-4839. eCollection 2020.