PMID- 32914676
OWN - NLM
STAT- MEDLINE
DCOM- 20210906
LR  - 20220421
IS  - 1556-9519 (Electronic)
IS  - 1556-3650 (Linking)
VI  - 59
IP  - 4
DP  - 2021 Apr
TI  - Trends in adverse events and related health-care facility utilization from cough 
      and cold medication exposures in children.
PG  - 351-354
LID - 10.1080/15563650.2020.1815761 [doi]
AB  - INTRODUCTION: Initial research following regulatory changes addressing the 
      pediatric safety of cough and cold medications (CCMs) demonstrated decreases in 
      adverse events (AEs). Using a national multi-source surveillance system, we 
      studied subsequent CCM-related AE case rate trends and associated health-care 
      facility (HCF) evaluation in children. METHODS: Data were collected from 2009 to 
      2016. Case eligibility included: age <12 years; exposure to an over-the-counter 
      product containing >/=1 CCM pharmaceutical ingredient; >/=1 significant AE that 
      occurred in the United States. RESULTS: About 4756 (72.6%) cases were determined 
      at least potentially related to an index ingredient. Accidental unsupervised 
      ingestions (AUIs; 3134; 65.9%) were the most common case type. Nearly half of AE 
      cases involved children 2 to <4 years old (2,159; 45.4%). The AE case rate did 
      not change significantly over time (p = 0.22). The proportion of AE cases 
      resulting in HCF admission increased from 32.4% (207) in 2009 to 43.4% (238) in 
      2016 (p < 0.01). Exposures to diphenhydramine (1,305; 67.3%) and/or 
      dextromethorphan (591; 30.5%) were involved in the majority of HCF admissions. 
      CONCLUSIONS: The proportion of AE cases resulting in HCF admission increased from 
      2009 to 2016. Efforts to prevent AUIs such as packaging innovation and 
      engineering controls, particularly for diphenhydramine and 
      dextromethorphan-containing products, should be pursued.
FAU - Wang, George Sam
AU  - Wang GS
AD  - Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, USA.
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
FAU - Green, Jody L
AU  - Green JL
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
FAU - Reynolds, Kate M
AU  - Reynolds KM
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
FAU - Banner, William
AU  - Banner W
AD  - Oklahoma Center for Poison and Drug Information, Oklahoma University College of 
      Pharmacy, Oklahoma City, OK, USA.
FAU - Bond, G Randall
AU  - Bond GR
AD  - Faculte de Medecine, Hope Africa University, Bujumbura, Burundi.
FAU - Kauffman, Ralph E
AU  - Kauffman RE
AD  - Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, 
      MO, USA.
FAU - Palmer, Robert B
AU  - Palmer RB
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
FAU - Paul, Ian M
AU  - Paul IM
AD  - Pediatrics & Public Health Sciences, Penn State College of Medicine, Hershey, PA, 
      USA.
FAU - Rapp-Olsson, Malin
AU  - Rapp-Olsson M
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
FAU - Dart, Richard C
AU  - Dart RC
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO, USA.
LA  - eng
PT  - Journal Article
DEP - 20200911
PL  - England
TA  - Clin Toxicol (Phila)
JT  - Clinical toxicology (Philadelphia, Pa.)
JID - 101241654
RN  - 0 (Antitussive Agents)
RN  - 0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
RN  - 0 (Nonprescription Drugs)
RN  - 7355X3ROTS (Dextromethorphan)
RN  - 8GTS82S83M (Diphenhydramine)
SB  - IM
MH  - Antitussive Agents/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dextromethorphan/adverse effects
MH  - Diphenhydramine/adverse effects
MH  - Humans
MH  - Multi-Ingredient Cold, Flu, and Allergy Medications/*adverse effects
MH  - Nonprescription Drugs/adverse effects
MH  - Patient Acceptance of Health Care/statistics & numerical data
MH  - Poison Control Centers/statistics & numerical data
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Pediatric safety surveillance
OT  - cough/cold medication safety
OT  - medication safety
OT  - sales-adjusted rates
OT  - trends
EDAT- 2020/09/12 06:00
MHDA- 2021/09/07 06:00
CRDT- 2020/09/11 08:38
PHST- 2020/09/12 06:00 [pubmed]
PHST- 2021/09/07 06:00 [medline]
PHST- 2020/09/11 08:38 [entrez]
AID - 10.1080/15563650.2020.1815761 [doi]
PST - ppublish
SO  - Clin Toxicol (Phila). 2021 Apr;59(4):351-354. doi: 10.1080/15563650.2020.1815761. 
      Epub 2020 Sep 11.