PMID- 32919144
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20201214
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 348
DP  - 2020 Nov 15
TI  - Serum level of IL-1beta in patients with inflammatory demyelinating disease: Marked 
      upregulation in the early acute phase of MOG antibody associated disease (MOGAD).
PG  - 577361
LID - S0165-5728(20)30184-3 [pii]
LID - 10.1016/j.jneuroim.2020.577361 [doi]
AB  - BACKGROUND: To evaluate the serum cytokine profiles in patients with myelin 
      oligodendrocyte glycoproteins antibody associated disease (MOGAD), compared to 
      those in neuromyelitis optica spectrum disorder with aquaporin-4 immunoglobulin G 
      (APQ4-IgG+ NMOSD), multiple sclerosis (MS), and other inflammatory demyelinating 
      diseases (IDDs). METHODS: The level of interleukin (IL)-1beta, IL-5, IL-6, IL-10, 
      IL-12p70, IL-17A, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma in sera 
      from 21 patients with MOGAD, 32 APQ4-IgG+ NMOSD, 24 MS, and 16 other IDDs were 
      assessed. RESULTS: In MOGAD patients, the levels of IL-1beta and IL-12p70 were 
      elevated compared to APQ4-IgG+ NMOSD. The level of IL-10 and the ratio of T 
      helper (Th)-1/Th2-related cytokines were elevated in MOGAD patients compared to 
      MS or other IDDs. In an intragroup analysis, the IL-1beta was increased in acute 
      stage of MOGAD, APQ4-IgG+ NMOSD, and also MS compared to their chronic stage 
      counterpart. It was inversely correlated with time from acute attack to sampling 
      in MOGAD (p < 0.001) and AQP4-IgG+ NMOSD (p = 0.001), but not in MS. Moreover, 
      the IL-1beta was most markedly upregulated in MOGAD sera sampled within 1 week from 
      acute attack compared to those sampled after (p = 0.002). CONCLUSIONS: The serum 
      IL-1beta can be elevated in the acute stage of patients with diverse IDDs including, 
      MOGAD, APQ4-IgG+ NMOSD, and MS. This upregulation of serum IL-1beta can be most 
      markedly observed in the early acute stage of MOGAD patients. Further studies 
      seem to be needed to determine the proper mechanism for the upregulation of serum 
      IL-1beta and also the role of IL-1beta inhibition especially at the early acute stage 
      of MOGAD.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Kwon, Young Nam
AU  - Kwon YN
AD  - Department of Neurology, Seoul National University Hospital, Seoul, Republic of 
      Korea; Department of Neurology, The Catholic University of Korea, Eunpyeong St. 
      Mary's Hospital, Seoul, Republic of Korea; Department of Medicine, Graduate 
      School, Kyung Hee University, Seoul, Republic of Korea.
FAU - Kim, Boram
AU  - Kim B
AD  - Department of Neurology, Seoul National University College of Medicine, 
      Neuroscience Research Institute, Seoul, Republic of Korea.
FAU - Ahn, Sohyun
AU  - Ahn S
AD  - Department of Neurology, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea.
FAU - Seo, Jaeyoung
AU  - Seo J
AD  - Department of Neurology, Seoul National University Hospital, Seoul, Republic of 
      Korea.
FAU - Kim, Sang Beom
AU  - Kim SB
AD  - Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, 
      Republic of Korea.
FAU - Yoon, Sung Sang
AU  - Yoon SS
AD  - Department of Neurology, Kyung Hee University Hospital, Seoul, Republic of Korea.
FAU - Sung, Jung-Joon
AU  - Sung JJ
AD  - Department of Neurology, Seoul National University Hospital, Seoul, Republic of 
      Korea; Department of Neurology, Seoul National University College of Medicine, 
      Neuroscience Research Institute, Seoul, Republic of Korea.
FAU - Choi, Youn Soo
AU  - Choi YS
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Department of Biomedical Sciences, Seoul National University 
      College of Medicine, Seoul, Republic of Korea. Electronic address: 
      younsoo94@snu.ac.kr.
FAU - Kim, Sung-Min
AU  - Kim SM
AD  - Department of Neurology, Seoul National University Hospital, Seoul, Republic of 
      Korea; Department of Neurology, Seoul National University College of Medicine, 
      Neuroscience Research Institute, Seoul, Republic of Korea. Electronic address: 
      sueh916@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200815
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Interleukin-1beta)
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Autoantibodies/immunology
MH  - Autoantigens/immunology
MH  - Demyelinating Autoimmune Diseases, CNS/*blood/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/*blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Myelin-Oligodendrocyte Glycoprotein/immunology
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - Cytokine
OT  - Interleukin 1
OT  - Myelin oligodendrocyte glycoprotein antibody associated disease
OT  - Neuromyelitis optica
OT  - Serum
EDAT- 2020/09/13 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/09/12 20:11
PHST- 2020/03/26 00:00 [received]
PHST- 2020/07/09 00:00 [revised]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/09/13 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/09/12 20:11 [entrez]
AID - S0165-5728(20)30184-3 [pii]
AID - 10.1016/j.jneuroim.2020.577361 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2020 Nov 15;348:577361. doi: 10.1016/j.jneuroim.2020.577361. Epub 
      2020 Aug 15.